FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978853119> ?p ?o ?g. }

• W1978853119 endingPage "685" @default.
• W1978853119 startingPage "678" @default.
• W1978853119 abstract "Background. The use of methylprednisolone (MP) and other corticosteroids for the treatment of acute liver allograft rejection is associated with severe toxicities in nontarget tissues. Therefore, selective delivery of MP to the liver may improve its efficacy and alleviate its side effects. We investigated the effects of a novel liver-targeted dextran prodrug of MP (DMP) in an orthotopic rat liver transplantation (OLT) model. Methods. The model consisted of a high responder rejection strain combination (Dark Agouti donors and Lewis recipients). Liver recipients were intravenously administered saline or a single subtherapeutic dose of MP (5 mg/kg) as the parent drug (MP) or its prodrug (DMP). Different groups were then monitored for graft survival or euthanized 5 or 9 days posttransplantation. Plasma chemistry, including alkaline phosphatase and bilirubin, allograft histology, and survival duration were determined. Results. Untreated recipients exhibited elevated plasma levels of liver injury markers, progressive portal and venous inflammation and cellular infiltration in liver allografts, and a mean graft survival time (MST) of 10.5 days. MP treatment did not alter any of these parameters. In contrast, a single dose of DMP resulted in a decrease in plasma levels of liver injury markers, a decrease in histological grade of rejection on day 5, and a substantial increase in MST (27.5 days). Conclusions. These results demonstrate attenuation of acute rejection following local (allograft) immunosuppression with a single subtherapeutic dose of MP delivered as a liver-targeted prodrug. Dextran prodrugs may be useful for selective delivery of immunosuppressants to the liver following liver transplantation." @default.
• W1978853119 created "2016-06-24" @default.
• W1978853119 creator A5013104727 @default.
• W1978853119 creator A5017648677 @default.
• W1978853119 creator A5018252207 @default.
• W1978853119 creator A5034139623 @default.
• W1978853119 creator A5034544046 @default.
• W1978853119 creator A5035771353 @default.
• W1978853119 creator A5035890041 @default.
• W1978853119 creator A5078802281 @default.
• W1978853119 date "2006-03-15" @default.
• W1978853119 modified "2023-10-02" @default.
• W1978853119 title "Attenuation of Acute Rejection in a Rat Liver Transplantation Model by a Liver-Targeted Dextran Prodrug of Methylprednisolone" @default.
• W1978853119 cites W165360772 @default.
• W1978853119 cites W1974770469 @default.
• W1978853119 cites W1979115410 @default.
• W1978853119 cites W1984014880 @default.
• W1978853119 cites W1986078858 @default.
• W1978853119 cites W1986989578 @default.
• W1978853119 cites W1992709251 @default.
• W1978853119 cites W1999503036 @default.
• W1978853119 cites W2005632921 @default.
• W1978853119 cites W2007221575 @default.
• W1978853119 cites W2018926253 @default.
• W1978853119 cites W2021671178 @default.
• W1978853119 cites W2022330879 @default.
• W1978853119 cites W2033128424 @default.
• W1978853119 cites W2033921394 @default.
• W1978853119 cites W2036006492 @default.
• W1978853119 cites W2037139145 @default.
• W1978853119 cites W2043931588 @default.
• W1978853119 cites W2045661009 @default.
• W1978853119 cites W2051864504 @default.
• W1978853119 cites W2052230654 @default.
• W1978853119 cites W2064576452 @default.
• W1978853119 cites W2065499176 @default.
• W1978853119 cites W2065739021 @default.
• W1978853119 cites W2071036303 @default.
• W1978853119 cites W2071776803 @default.
• W1978853119 cites W2073086799 @default.
• W1978853119 cites W2073234972 @default.
• W1978853119 cites W2082902889 @default.
• W1978853119 cites W2090736844 @default.
• W1978853119 cites W2113503823 @default.
• W1978853119 cites W2128092549 @default.
• W1978853119 cites W2128434381 @default.
• W1978853119 cites W2150310611 @default.
• W1978853119 cites W2163721979 @default.
• W1978853119 cites W2163785845 @default.
• W1978853119 cites W2316902707 @default.
• W1978853119 cites W2336677620 @default.
• W1978853119 cites W2395054583 @default.
• W1978853119 cites W2404547078 @default.
• W1978853119 cites W2410980729 @default.
• W1978853119 cites W2411790276 @default.
• W1978853119 cites W2419366096 @default.
• W1978853119 cites W2419730934 @default.
• W1978853119 cites W2437863906 @default.
• W1978853119 cites W4241515584 @default.
• W1978853119 cites W4253896231 @default.
• W1978853119 cites W42684369 @default.
• W1978853119 cites W4290169290 @default.
• W1978853119 cites W4299502530 @default.
• W1978853119 cites W47650731 @default.
• W1978853119 cites W51187056 @default.
• W1978853119 doi "https://doi.org/10.1097/01.tp.0000177654.48112.b6" @default.
• W1978853119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1483062" @default.
• W1978853119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16534468" @default.
• W1978853119 hasPublicationYear "2006" @default.
• W1978853119 type Work @default.
• W1978853119 sameAs 1978853119 @default.
• W1978853119 citedByCount "14" @default.
• W1978853119 countsByYear W19788531192012 @default.
• W1978853119 countsByYear W19788531192016 @default.
• W1978853119 countsByYear W19788531192017 @default.
• W1978853119 countsByYear W19788531192018 @default.
• W1978853119 countsByYear W19788531192021 @default.
• W1978853119 crossrefType "journal-article" @default.
• W1978853119 hasAuthorship W1978853119A5013104727 @default.
• W1978853119 hasAuthorship W1978853119A5017648677 @default.
• W1978853119 hasAuthorship W1978853119A5018252207 @default.
• W1978853119 hasAuthorship W1978853119A5034139623 @default.
• W1978853119 hasAuthorship W1978853119A5034544046 @default.
• W1978853119 hasAuthorship W1978853119A5035771353 @default.
• W1978853119 hasAuthorship W1978853119A5035890041 @default.
• W1978853119 hasAuthorship W1978853119A5078802281 @default.
• W1978853119 hasBestOaLocation W19788531191 @default.
• W1978853119 hasConcept C108215921 @default.
• W1978853119 hasConcept C112705442 @default.
• W1978853119 hasConcept C126322002 @default.
• W1978853119 hasConcept C185592680 @default.
• W1978853119 hasConcept C203014093 @default.
• W1978853119 hasConcept C2776637226 @default.
• W1978853119 hasConcept C2777339698 @default.
• W1978853119 hasConcept C2777513400 @default.
• W1978853119 hasConcept C2779609443 @default.
• W1978853119 hasConcept C2780252810 @default.
• W1978853119 hasConcept C2780372218 @default.

• next