Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978865140> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1978865140 endingPage "146" @default.
- W1978865140 startingPage "140" @default.
- W1978865140 abstract "Eslicarbazepine acetate (BIA 2-093, S-(-)-10-acetoxy-10,11-dihydro-5H-dibenzo/b,f/azepine-5-carboxamide) is a novel antiepileptic drug, now in Phase III clinical trials, designed with the aim of improving efficacy and safety in comparison with the structurally related drugs carbamazepine (CBZ) and oxcarbazepine (OXC). We have studied the effects of oral treatment with eslicarbazepine acetate on a whole-animal model in which partial seizures can be elicited repeatedly on different days without changes in threshold or seizure patterns. In the animals treated with threshold doses of picrotoxin, the average number of seizures was 2.3+/-1.2, and average seizure duration was 39.5+/-8.4s. Pre-treatment with a dose of 30 mg/kg 2h before picrotoxin microperfusion prevented seizures in the 75% of the rats. Lower doses (3 and 10mg/kg) did not suppress seizures, however, after administration of 10mg/kg, significant reductions in seizures duration (24.3+/-6.8s) and seizure number (1.6+/-0.34) were found. No adverse effects of eslicarbazepine acetate were observed in the behavioral/EEG patterns studied, including sleep/wakefulness cycle, at the doses studied." @default.
- W1978865140 created "2016-06-24" @default.
- W1978865140 creator A5014036266 @default.
- W1978865140 creator A5022956347 @default.
- W1978865140 creator A5038040613 @default.
- W1978865140 creator A5072768546 @default.
- W1978865140 creator A5084630250 @default.
- W1978865140 date "2006-12-01" @default.
- W1978865140 modified "2023-10-11" @default.
- W1978865140 title "Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats" @default.
- W1978865140 cites W1557552045 @default.
- W1978865140 cites W1977096973 @default.
- W1978865140 cites W1994985459 @default.
- W1978865140 cites W1995660607 @default.
- W1978865140 cites W1998249177 @default.
- W1978865140 cites W2014281284 @default.
- W1978865140 cites W2024607510 @default.
- W1978865140 cites W2040273455 @default.
- W1978865140 cites W2042039353 @default.
- W1978865140 cites W2071379868 @default.
- W1978865140 cites W2083971852 @default.
- W1978865140 cites W2086759170 @default.
- W1978865140 cites W2114440648 @default.
- W1978865140 cites W2132812107 @default.
- W1978865140 cites W2162729385 @default.
- W1978865140 cites W2163815564 @default.
- W1978865140 cites W2165021119 @default.
- W1978865140 cites W219357105 @default.
- W1978865140 cites W2320849562 @default.
- W1978865140 doi "https://doi.org/10.1016/j.eplepsyres.2006.07.010" @default.
- W1978865140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16920333" @default.
- W1978865140 hasPublicationYear "2006" @default.
- W1978865140 type Work @default.
- W1978865140 sameAs 1978865140 @default.
- W1978865140 citedByCount "15" @default.
- W1978865140 countsByYear W19788651402014 @default.
- W1978865140 countsByYear W19788651402015 @default.
- W1978865140 countsByYear W19788651402016 @default.
- W1978865140 countsByYear W19788651402017 @default.
- W1978865140 countsByYear W19788651402021 @default.
- W1978865140 crossrefType "journal-article" @default.
- W1978865140 hasAuthorship W1978865140A5014036266 @default.
- W1978865140 hasAuthorship W1978865140A5022956347 @default.
- W1978865140 hasAuthorship W1978865140A5038040613 @default.
- W1978865140 hasAuthorship W1978865140A5072768546 @default.
- W1978865140 hasAuthorship W1978865140A5084630250 @default.
- W1978865140 hasConcept C118552586 @default.
- W1978865140 hasConcept C126322002 @default.
- W1978865140 hasConcept C170493617 @default.
- W1978865140 hasConcept C2775858608 @default.
- W1978865140 hasConcept C2776885963 @default.
- W1978865140 hasConcept C2776895053 @default.
- W1978865140 hasConcept C2777056318 @default.
- W1978865140 hasConcept C2778186239 @default.
- W1978865140 hasConcept C2778460930 @default.
- W1978865140 hasConcept C2779253243 @default.
- W1978865140 hasConcept C2779324764 @default.
- W1978865140 hasConcept C2781176495 @default.
- W1978865140 hasConcept C42219234 @default.
- W1978865140 hasConcept C71924100 @default.
- W1978865140 hasConcept C98274493 @default.
- W1978865140 hasConceptScore W1978865140C118552586 @default.
- W1978865140 hasConceptScore W1978865140C126322002 @default.
- W1978865140 hasConceptScore W1978865140C170493617 @default.
- W1978865140 hasConceptScore W1978865140C2775858608 @default.
- W1978865140 hasConceptScore W1978865140C2776885963 @default.
- W1978865140 hasConceptScore W1978865140C2776895053 @default.
- W1978865140 hasConceptScore W1978865140C2777056318 @default.
- W1978865140 hasConceptScore W1978865140C2778186239 @default.
- W1978865140 hasConceptScore W1978865140C2778460930 @default.
- W1978865140 hasConceptScore W1978865140C2779253243 @default.
- W1978865140 hasConceptScore W1978865140C2779324764 @default.
- W1978865140 hasConceptScore W1978865140C2781176495 @default.
- W1978865140 hasConceptScore W1978865140C42219234 @default.
- W1978865140 hasConceptScore W1978865140C71924100 @default.
- W1978865140 hasConceptScore W1978865140C98274493 @default.
- W1978865140 hasIssue "2-3" @default.
- W1978865140 hasLocation W19788651401 @default.
- W1978865140 hasLocation W19788651402 @default.
- W1978865140 hasOpenAccess W1978865140 @default.
- W1978865140 hasPrimaryLocation W19788651401 @default.
- W1978865140 hasRelatedWork W1978865140 @default.
- W1978865140 hasRelatedWork W2061082755 @default.
- W1978865140 hasRelatedWork W2085930005 @default.
- W1978865140 hasRelatedWork W2098549463 @default.
- W1978865140 hasRelatedWork W2413107201 @default.
- W1978865140 hasRelatedWork W2529776038 @default.
- W1978865140 hasRelatedWork W2775534250 @default.
- W1978865140 hasRelatedWork W2921600023 @default.
- W1978865140 hasRelatedWork W2942052295 @default.
- W1978865140 hasRelatedWork W2966700863 @default.
- W1978865140 hasVolume "72" @default.
- W1978865140 isParatext "false" @default.
- W1978865140 isRetracted "false" @default.
- W1978865140 magId "1978865140" @default.
- W1978865140 workType "article" @default.