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• W1978867544 abstract "El endotelio desempeña un papel clave en la regulación de la función vascular al liberar, en respuesta a distintos estímulos, numerosos factores vasoactivos. La hiperlipidemia, así como otros factores de riesgo cardiovascular, alteran ese papel homeostático que desempeña el endotelio en la regulación de la función vascular. Uno de los mecanismos fundamentales que subyacen a la disfunción endotelial parece ser una disminución en la disponibilidad de óxido nítrico (NO), lo que permite la sobreexpresión de las acciones de factores que se oponen a los efectos beneficiosos y protectores de éste sobre la pared vascular. Diversos mecanismos podrían ser responsables de esta menor disponibilidad de NO, desde alteraciones en su síntesis a una mayor degradación como consecuencia de un aumento del estrés oxidativo. En pacientes hipercolesterolémicos la reducción de los niveles de colesterol conlleva una mejoría de la función endotelial, lo que indicaría que la elevación de dichos niveles podría activar diversos mecanismos que alteraran el normal funcionamiento del endotelio. Sin embargo, existen otros grupos de fármacos, como los antioxidantes o los que bloquean el sistema renina-angiotensina, que han demostrado un efecto beneficioso sobre la función endotelial tanto en estudios clínicos como experimentales. Endothelium plays a key role in the regulation of vascular function by releasing numerous vasoactive factors. This release occurs in response to different stimuli. Dyslipidemia, as well as other cardiovascular risk factors, alters the homeostatic role that the endothelium exerts on vascular function. One of the main mechanisms underlying the endothelial dysfunction associated with dyslipidemia seems to be a decrease in nitric oxide (NO) availability. This situation allows the over-expression of factors that exert actions which oppose the beneficial and protective effects of NO on the vascular wall. Several mechanisms could account for the minor NO availability in hyperlipidemia, including changes in NO synthesis and a major degradation due to an increase in oxidative stress. In patients with hypercholesterolemia the reduction in plasma lipids is associated with amelioration of endothelial function. This suggests the important role of high cholesterol plasma levels in the alteration of endothelial function in hypercholesterolemia. However, there are other drugs that can improve endothelial function in dyslipidemia in both clinical and experimental studies such as antioxidants and drugs that interact with the renin-angiotensin system." @default.
• W1978867544 created "2016-06-24" @default.
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• W1978867544 date "2003-01-01" @default.
• W1978867544 modified "2023-10-14" @default.
• W1978867544 title "Hipercolesterolemia y disfunción endotelial: mecanismos implicados" @default.
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• W1978867544 doi "https://doi.org/10.1016/s1889-1837(03)71363-4" @default.
• W1978867544 hasPublicationYear "2003" @default.
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