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- W1978880212 abstract "It is 52 years since the discovery that autoimmunity is the main cause of thyroid dysfunction. Following the seminal observations of Noel Rose and Ernest Witebsky, who immunized rabbits with crude thyroid extract and showed that this resulted in the production of thyroglobulin antibodies and thyroiditis, it was quickly appreciated by Roitt and Doniach that the similar process of autoimmunization accounted for “lymphadenoid goiter” or Hashimoto thyroiditis. These observations flew in the face of the then current view that the body would not mount an immune response against self-proteins, and of course, since that time many other disorders have been found to have their roots in autoimmunity. Nonetheless, we still have only a partial insight into the factors that cause autoimmune disease to occur, and in this short commentary I will outline some of the many contributions that John Lazarus has made to our understanding of the autoimmune process and how it might be modulated." @default.
- W1978880212 created "2016-06-24" @default.
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- W1978880212 date "2009-01-01" @default.
- W1978880212 modified "2023-09-24" @default.
- W1978880212 title "“Ioning” Out Thyroid Autoimmunity" @default.
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- W1978880212 doi "https://doi.org/10.4158/ep.15.1.53" @default.
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