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• W1978885265 abstract "Catechol estrogens, such as 4-hydroxyestradiol (4-OHE2), are estrogen metabolites that form DNA adducts and may induce mutations and subsequent cell transformation in mammary cells; however, little is known about their roles in endometrial carcinogenesis. Furthermore, it remains unclear whether 4-OHE2 is able to induce DNA damage on specific genes involved in carcinogenesis or a 'pro'-mutation status such as microsatellite instability (MSI). Therefore, we modified terminal transferase-dependent PCR by the application of a capillary sequencer to detect DNA damage at the single base level. Using this method, we demonstrated that 4-OHE2 directly induced DNA damage on codon 130/131 in exon 5 of PTEN, which is a mutation hot spot for PTEN in endometrial carcinoma. Whereas, both estradiol and 4-OHE2 treatment did not affect MSI status in immortalized endometrial glandular cells. 4-OHE2 might contribute to endometrial carcinogenesis by inducing PTEN mutation on codon 130/131." @default.
• W1978885265 created "2016-06-24" @default.
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• W1978885265 date "2015-01-01" @default.
• W1978885265 modified "2023-09-24" @default.
• W1978885265 title "4-hydroxy estrogen induces DNA damage on codon 130/131 of PTEN in endometrial carcinoma cells" @default.
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• W1978885265 doi "https://doi.org/10.1016/j.mce.2014.10.027" @default.
• W1978885265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25449419" @default.
• W1978885265 hasPublicationYear "2015" @default.
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