Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978889707> ?p ?o ?g. }
- W1978889707 endingPage "1351" @default.
- W1978889707 startingPage "1333" @default.
- W1978889707 abstract "Adrenergic receptors belong to the seven transmembrane spanning, G-protein-coupled receptor super family, which mediate the actions of the endogenous catecholamines, adrenaline and noradrenaline (also known as epinephrine and norepinephrine). Adrenergic receptors are involved in several disease states such as hypertension, cardiac dysfunction, diabetes, glaucoma, depression, impotence and lower urinary tract disorders. This makes adrenergic receptors a valuable therapeutic target for the treatment of various disorders. Adrenergic receptors are broadly categorised into α1-,α2- and β-subtypes. Of these, α1-adrenoceptors, located in both central and peripheral nervous systems, are of great therapeutic relevance because of their important role in the contraction of smooth muscle tissue, especially in the cardiovascular system and lower urinary tract. The α1-adrenoceptor subtype has been further divided into α1A, α1B and α1D and ligands acting at these subtypes have therapeutic potential in the treatment of hypertension, stress urinary incontinence (SUI), benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). This review summarises the patent literature from 2001 to early 2005 on the development of selective ligands of the α1-adrenoceptor and its subtypes." @default.
- W1978889707 created "2016-06-24" @default.
- W1978889707 creator A5017005427 @default.
- W1978889707 creator A5068554724 @default.
- W1978889707 creator A5086070801 @default.
- W1978889707 date "2005-09-30" @default.
- W1978889707 modified "2023-09-25" @default.
- W1978889707 title "α1-Adrenoceptors as potential therapeutic targets" @default.
- W1978889707 cites W1480646162 @default.
- W1978889707 cites W1538183895 @default.
- W1978889707 cites W1602728552 @default.
- W1978889707 cites W1970723337 @default.
- W1978889707 cites W1978253417 @default.
- W1978889707 cites W1979254549 @default.
- W1978889707 cites W1981135552 @default.
- W1978889707 cites W1981897795 @default.
- W1978889707 cites W1982657636 @default.
- W1978889707 cites W1985407755 @default.
- W1978889707 cites W1985923344 @default.
- W1978889707 cites W1988858269 @default.
- W1978889707 cites W1990110164 @default.
- W1978889707 cites W1990732773 @default.
- W1978889707 cites W1993624584 @default.
- W1978889707 cites W1998734661 @default.
- W1978889707 cites W2000119690 @default.
- W1978889707 cites W2000643141 @default.
- W1978889707 cites W2004507156 @default.
- W1978889707 cites W2005074906 @default.
- W1978889707 cites W2005717850 @default.
- W1978889707 cites W2006661246 @default.
- W1978889707 cites W2007954970 @default.
- W1978889707 cites W2008094142 @default.
- W1978889707 cites W2008129012 @default.
- W1978889707 cites W2009783960 @default.
- W1978889707 cites W2010740081 @default.
- W1978889707 cites W2013891074 @default.
- W1978889707 cites W2017128176 @default.
- W1978889707 cites W2017436626 @default.
- W1978889707 cites W2020320506 @default.
- W1978889707 cites W2021420428 @default.
- W1978889707 cites W2021570089 @default.
- W1978889707 cites W2024773645 @default.
- W1978889707 cites W2034792871 @default.
- W1978889707 cites W2035986648 @default.
- W1978889707 cites W2037890165 @default.
- W1978889707 cites W2045711694 @default.
- W1978889707 cites W2049564609 @default.
- W1978889707 cites W2050349060 @default.
- W1978889707 cites W2058005021 @default.
- W1978889707 cites W2058173255 @default.
- W1978889707 cites W2060435183 @default.
- W1978889707 cites W2066339316 @default.
- W1978889707 cites W2069730836 @default.
- W1978889707 cites W2071502429 @default.
- W1978889707 cites W2072039564 @default.
- W1978889707 cites W2072088822 @default.
- W1978889707 cites W2075907691 @default.
- W1978889707 cites W2084510672 @default.
- W1978889707 cites W2086157441 @default.
- W1978889707 cites W2086449586 @default.
- W1978889707 cites W2088160829 @default.
- W1978889707 cites W2101628891 @default.
- W1978889707 cites W2102305767 @default.
- W1978889707 cites W2107795177 @default.
- W1978889707 cites W2107838994 @default.
- W1978889707 cites W2108676657 @default.
- W1978889707 cites W2113545613 @default.
- W1978889707 cites W2121759271 @default.
- W1978889707 cites W2124980716 @default.
- W1978889707 cites W2132212260 @default.
- W1978889707 cites W2140869466 @default.
- W1978889707 cites W2155055420 @default.
- W1978889707 cites W2159758008 @default.
- W1978889707 cites W2163825683 @default.
- W1978889707 cites W2167191243 @default.
- W1978889707 cites W2167955976 @default.
- W1978889707 cites W2169858377 @default.
- W1978889707 cites W22773603 @default.
- W1978889707 cites W2322609729 @default.
- W1978889707 cites W4242830497 @default.
- W1978889707 doi "https://doi.org/10.1517/13543776.15.10.1333" @default.
- W1978889707 hasPublicationYear "2005" @default.
- W1978889707 type Work @default.
- W1978889707 sameAs 1978889707 @default.
- W1978889707 citedByCount "8" @default.
- W1978889707 countsByYear W19788897072013 @default.
- W1978889707 countsByYear W19788897072017 @default.
- W1978889707 crossrefType "journal-article" @default.
- W1978889707 hasAuthorship W1978889707A5017005427 @default.
- W1978889707 hasAuthorship W1978889707A5068554724 @default.
- W1978889707 hasAuthorship W1978889707A5086070801 @default.
- W1978889707 hasConcept C121608353 @default.
- W1978889707 hasConcept C126322002 @default.
- W1978889707 hasConcept C134018914 @default.
- W1978889707 hasConcept C158453852 @default.
- W1978889707 hasConcept C170493617 @default.
- W1978889707 hasConcept C2775859304 @default.
- W1978889707 hasConcept C2776235491 @default.