Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978892685> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1978892685 endingPage "2193" @default.
- W1978892685 startingPage "2188" @default.
- W1978892685 abstract "The kinetics of hydrolysis of a series of 10 new hippurate esters (C 6 H 5 CONHCH 2 CO 2 CRR 1 CO 2 H (I)) by bovine pancreatic carboxypeptidase A have been investigated at pH 7.5, 25 °C, and ionic strength 0.5. Pronounced substrate inhibition was displayed by I: R = H, R 1 = C 6 H 5 (CH 2 ) 2 , 3-indolylmethyl, 4-HOC 6 H 4 CH 2 , and 4-FC 6 H 4 whereas pronounced substrate activation was observed for I: R = H, R 1 = 4-CH 3 C 6 H 4 , 4-C 2 H 5 C 6 H 4 , 4-C 6 H 5 C 6 H 4 , 1-naphthyl, 2-naphthyl, and R = R 1 = C 2 H 5 . In all cases substrate activation and substrate inhibition were shown to be consistent with ES 2 complex formation similar to that previously observed for other hippurate esters. Kinetic parameters were evaluated for each ester and it is noted that ail 13 hippurate esters now known to display substrate inhibition have k cat /K m > 10 6 M −1 min −1 , whereas k cat /k m < 10 6 M −1 min −1 for all 9 hippurate esters known to display substrate activation. The enzymic specificity for the R 1 unit of I suggests binding of R 1 in a 'bent' hydrophobic pocket having a restricted entrance." @default.
- W1978892685 created "2016-06-24" @default.
- W1978892685 creator A5030123363 @default.
- W1978892685 creator A5077388202 @default.
- W1978892685 date "1978-08-15" @default.
- W1978892685 modified "2023-09-26" @default.
- W1978892685 title "Further studies of the specificity of carboxypeptidase A towards hippuric acid esters" @default.
- W1978892685 doi "https://doi.org/10.1139/v78-358" @default.
- W1978892685 hasPublicationYear "1978" @default.
- W1978892685 type Work @default.
- W1978892685 sameAs 1978892685 @default.
- W1978892685 citedByCount "0" @default.
- W1978892685 crossrefType "journal-article" @default.
- W1978892685 hasAuthorship W1978892685A5030123363 @default.
- W1978892685 hasAuthorship W1978892685A5077388202 @default.
- W1978892685 hasConcept C108477463 @default.
- W1978892685 hasConcept C111368507 @default.
- W1978892685 hasConcept C121332964 @default.
- W1978892685 hasConcept C127313418 @default.
- W1978892685 hasConcept C136398272 @default.
- W1978892685 hasConcept C148898269 @default.
- W1978892685 hasConcept C181199279 @default.
- W1978892685 hasConcept C185592680 @default.
- W1978892685 hasConcept C2777289219 @default.
- W1978892685 hasConcept C2780026642 @default.
- W1978892685 hasConcept C2780548424 @default.
- W1978892685 hasConcept C55493867 @default.
- W1978892685 hasConcept C62520636 @default.
- W1978892685 hasConcept C71240020 @default.
- W1978892685 hasConcept C94412978 @default.
- W1978892685 hasConceptScore W1978892685C108477463 @default.
- W1978892685 hasConceptScore W1978892685C111368507 @default.
- W1978892685 hasConceptScore W1978892685C121332964 @default.
- W1978892685 hasConceptScore W1978892685C127313418 @default.
- W1978892685 hasConceptScore W1978892685C136398272 @default.
- W1978892685 hasConceptScore W1978892685C148898269 @default.
- W1978892685 hasConceptScore W1978892685C181199279 @default.
- W1978892685 hasConceptScore W1978892685C185592680 @default.
- W1978892685 hasConceptScore W1978892685C2777289219 @default.
- W1978892685 hasConceptScore W1978892685C2780026642 @default.
- W1978892685 hasConceptScore W1978892685C2780548424 @default.
- W1978892685 hasConceptScore W1978892685C55493867 @default.
- W1978892685 hasConceptScore W1978892685C62520636 @default.
- W1978892685 hasConceptScore W1978892685C71240020 @default.
- W1978892685 hasConceptScore W1978892685C94412978 @default.
- W1978892685 hasIssue "16" @default.
- W1978892685 hasLocation W19788926851 @default.
- W1978892685 hasOpenAccess W1978892685 @default.
- W1978892685 hasPrimaryLocation W19788926851 @default.
- W1978892685 hasRelatedWork W174922074 @default.
- W1978892685 hasRelatedWork W1976424056 @default.
- W1978892685 hasRelatedWork W1978626972 @default.
- W1978892685 hasRelatedWork W1983057836 @default.
- W1978892685 hasRelatedWork W1991201552 @default.
- W1978892685 hasRelatedWork W1995545479 @default.
- W1978892685 hasRelatedWork W2012539813 @default.
- W1978892685 hasRelatedWork W2086618833 @default.
- W1978892685 hasRelatedWork W2463164655 @default.
- W1978892685 hasRelatedWork W3043240263 @default.
- W1978892685 hasVolume "56" @default.
- W1978892685 isParatext "false" @default.
- W1978892685 isRetracted "false" @default.
- W1978892685 magId "1978892685" @default.
- W1978892685 workType "article" @default.