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- W1978893044 abstract "THE INTERACTION between cyclosporine A (CsA) and diltiazem that results in increased CsA blood concentration has been established previously. Both drugs are cytochrome P450 3A4 substrates, and their interaction explained by competitive inhibition of CsA metabolism in the liver. Calcium channels blockers (CCB) are useful in preventing CsA nephrotoxicity. Cotreatment with CCB has been postulated to improve early graft function, reduce acute rejection, and decrease the incidence of delayed graft function. The effect of cotreatment with the CCB diltiazem on the pharmacokinetic of the new microemulsion formulation of CsA (Neoral) and its metabolites has not been specifically examined in adults." @default.
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- W1978893044 date "1998-08-01" @default.
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- W1978893044 title "Study of neoral kinetics in adult renal transplantation treated with diltiazem" @default.
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- W1978893044 doi "https://doi.org/10.1016/s0041-1345(98)00381-9" @default.
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