Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978895230> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1978895230 endingPage "65" @default.
- W1978895230 startingPage "57" @default.
- W1978895230 abstract "Background In response to increasing antibiotic resistance, vancomycin has been proposed as an alternative prophylactic agent in TKA. However, vancomycin requires a prolonged administration time, risks promoting further antibiotic resistance, and can cause systemic toxicity. Intraosseous regional administration (IORA) is known to achieve markedly higher antibiotic concentrations than systemic administration and may allow the use of a lower vancomycin dose. Questions/purposes We assessed whether low-dose IORA vancomycin can achieve tissue concentrations equal or superior to those of systemic administration in TKA and compared complications between patients treated with IORA and intravenous vancomycin. Methods We randomized 30 patients undergoing primary TKA to receive 250 or 500 mg vancomycin via IORA or 1 g via systemic administration. IORA was performed as a bolus injection into a tibial intraosseous cannula below an inflated thigh tourniquet immediately before skin incision. Subcutaneous fat and bone samples were taken during the procedure and antibiotic concentrations measured. Results The overall mean tissue concentration of vancomycin in subcutaneous fat was 14 μg/g in the 250-mg IORA group, 44 μg/g in the 500-mg IORA group, and 3.2 μg/g in the systemic group. Mean concentrations in bone were 16 μg/g in the 250-mg IORA group, 38 μg/g in the 500-mg IORA group, and 4.0 μg/g in the systemic group. One patient in the systemic group developed red man syndrome during infusion. Conclusions Low-dose IORA vancomycin results in tissue concentrations equal or superior to those of systemic administration. IORA optimizes timing of vancomycin administration, and the lower dose may reduce the risk of systemic side effects while providing equal or enhanced prophylaxis in TKA. Level of Evidence Level I, therapeutic study. See the Instructions for Authors for a complete description of levels of evidence." @default.
- W1978895230 created "2016-06-24" @default.
- W1978895230 creator A5036384620 @default.
- W1978895230 creator A5048154200 @default.
- W1978895230 creator A5051993838 @default.
- W1978895230 creator A5061904347 @default.
- W1978895230 creator A5075697277 @default.
- W1978895230 creator A5076475478 @default.
- W1978895230 date "2014-01-01" @default.
- W1978895230 modified "2023-09-24" @default.
- W1978895230 title "The Mark Coventry Award: Higher Tissue Concentrations of Vancomycin With Low-dose Intraosseous Regional Versus Systemic Prophylaxis in TKA" @default.
- W1978895230 cites W2133315994 @default.
- W1978895230 cites W74132702 @default.
- W1978895230 doi "https://doi.org/10.1007/s11999-013-3038-z" @default.
- W1978895230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3889447" @default.
- W1978895230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23666589" @default.
- W1978895230 hasPublicationYear "2014" @default.
- W1978895230 type Work @default.
- W1978895230 sameAs 1978895230 @default.
- W1978895230 citedByCount "46" @default.
- W1978895230 countsByYear W19788952302013 @default.
- W1978895230 countsByYear W19788952302014 @default.
- W1978895230 countsByYear W19788952302015 @default.
- W1978895230 countsByYear W19788952302016 @default.
- W1978895230 countsByYear W19788952302017 @default.
- W1978895230 countsByYear W19788952302018 @default.
- W1978895230 countsByYear W19788952302019 @default.
- W1978895230 countsByYear W19788952302020 @default.
- W1978895230 countsByYear W19788952302021 @default.
- W1978895230 countsByYear W19788952302022 @default.
- W1978895230 countsByYear W19788952302023 @default.
- W1978895230 crossrefType "journal-article" @default.
- W1978895230 hasAuthorship W1978895230A5036384620 @default.
- W1978895230 hasAuthorship W1978895230A5048154200 @default.
- W1978895230 hasAuthorship W1978895230A5051993838 @default.
- W1978895230 hasAuthorship W1978895230A5061904347 @default.
- W1978895230 hasAuthorship W1978895230A5075697277 @default.
- W1978895230 hasAuthorship W1978895230A5076475478 @default.
- W1978895230 hasBestOaLocation W19788952302 @default.
- W1978895230 hasConcept C141071460 @default.
- W1978895230 hasConcept C150903083 @default.
- W1978895230 hasConcept C207001950 @default.
- W1978895230 hasConcept C25938499 @default.
- W1978895230 hasConcept C2778980435 @default.
- W1978895230 hasConcept C2779489039 @default.
- W1978895230 hasConcept C3019325995 @default.
- W1978895230 hasConcept C42219234 @default.
- W1978895230 hasConcept C43376680 @default.
- W1978895230 hasConcept C501593827 @default.
- W1978895230 hasConcept C523546767 @default.
- W1978895230 hasConcept C54355233 @default.
- W1978895230 hasConcept C71924100 @default.
- W1978895230 hasConcept C86803240 @default.
- W1978895230 hasConcept C89423630 @default.
- W1978895230 hasConceptScore W1978895230C141071460 @default.
- W1978895230 hasConceptScore W1978895230C150903083 @default.
- W1978895230 hasConceptScore W1978895230C207001950 @default.
- W1978895230 hasConceptScore W1978895230C25938499 @default.
- W1978895230 hasConceptScore W1978895230C2778980435 @default.
- W1978895230 hasConceptScore W1978895230C2779489039 @default.
- W1978895230 hasConceptScore W1978895230C3019325995 @default.
- W1978895230 hasConceptScore W1978895230C42219234 @default.
- W1978895230 hasConceptScore W1978895230C43376680 @default.
- W1978895230 hasConceptScore W1978895230C501593827 @default.
- W1978895230 hasConceptScore W1978895230C523546767 @default.
- W1978895230 hasConceptScore W1978895230C54355233 @default.
- W1978895230 hasConceptScore W1978895230C71924100 @default.
- W1978895230 hasConceptScore W1978895230C86803240 @default.
- W1978895230 hasConceptScore W1978895230C89423630 @default.
- W1978895230 hasIssue "1" @default.
- W1978895230 hasLocation W19788952301 @default.
- W1978895230 hasLocation W19788952302 @default.
- W1978895230 hasLocation W19788952303 @default.
- W1978895230 hasLocation W19788952304 @default.
- W1978895230 hasOpenAccess W1978895230 @default.
- W1978895230 hasPrimaryLocation W19788952301 @default.
- W1978895230 hasRelatedWork W1977402413 @default.
- W1978895230 hasRelatedWork W2019302806 @default.
- W1978895230 hasRelatedWork W2026768825 @default.
- W1978895230 hasRelatedWork W2047967234 @default.
- W1978895230 hasRelatedWork W2069253116 @default.
- W1978895230 hasRelatedWork W2197043389 @default.
- W1978895230 hasRelatedWork W2292253603 @default.
- W1978895230 hasRelatedWork W25740002 @default.
- W1978895230 hasRelatedWork W2803248938 @default.
- W1978895230 hasRelatedWork W942296153 @default.
- W1978895230 hasVolume "472" @default.
- W1978895230 isParatext "false" @default.
- W1978895230 isRetracted "false" @default.
- W1978895230 magId "1978895230" @default.
- W1978895230 workType "article" @default.