Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978897589> ?p ?o ?g. }
- W1978897589 endingPage "2995" @default.
- W1978897589 startingPage "2986" @default.
- W1978897589 abstract "Features of the Th1 or Th2 phenotype start to develop during CD4 T cell priming. This study of the response to the bacterial flagellar protein FliC shows that either Th1 or Th2 responses can be induced in mice depending upon how FliC is presented. This is shown by assessing the cytokine mRNA and class of FliC-specific plasma cells induced in situ. Soluble recombinant (r)FliC and polymerized FliC are strongly Th2 polarizing, inducing IL-4, NIP45 and c-Maf mRNA as well as epsilon and gamma1 switch transcripts and switching to IgG1. CD28-requirement for this switching shows its T cell dependence. rFliC was unable to induce markers of Th1 activity including IL-12, T-bet and IFN-gamma. Conversely, when FliC is presented in its native context surface-bound on live, flagellated Salmonella, switching is predominantly to IgG2a (IgG2c in C57BL/6 mice), reflecting Th1 activity. The development of divergent FliC-specific polarization to either Th1 or Th2 indicates that the context in which this antigen is encountered rather than its intrinsic immunostimulatory properties determines the direction of Th polarization." @default.
- W1978897589 created "2016-06-24" @default.
- W1978897589 creator A5017271872 @default.
- W1978897589 creator A5027010008 @default.
- W1978897589 creator A5033100102 @default.
- W1978897589 creator A5050963939 @default.
- W1978897589 creator A5059026139 @default.
- W1978897589 creator A5064498653 @default.
- W1978897589 creator A5084920681 @default.
- W1978897589 date "2004-10-11" @default.
- W1978897589 modified "2023-10-12" @default.
- W1978897589 title "Responses to the soluble flagellar protein FliC are Th2, while those to FliC onSalmonella are Th1" @default.
- W1978897589 cites W1519633296 @default.
- W1978897589 cites W1571805068 @default.
- W1978897589 cites W1655860314 @default.
- W1978897589 cites W1661544713 @default.
- W1978897589 cites W1671931635 @default.
- W1978897589 cites W1873495658 @default.
- W1978897589 cites W1918530663 @default.
- W1978897589 cites W1939780676 @default.
- W1978897589 cites W1967261754 @default.
- W1978897589 cites W1971459266 @default.
- W1978897589 cites W1972261522 @default.
- W1978897589 cites W1988707760 @default.
- W1978897589 cites W1994094189 @default.
- W1978897589 cites W2003310898 @default.
- W1978897589 cites W2006738527 @default.
- W1978897589 cites W2016755802 @default.
- W1978897589 cites W2026176809 @default.
- W1978897589 cites W2027983878 @default.
- W1978897589 cites W2038271225 @default.
- W1978897589 cites W2042048278 @default.
- W1978897589 cites W2043189165 @default.
- W1978897589 cites W2047151651 @default.
- W1978897589 cites W2054517109 @default.
- W1978897589 cites W2075948284 @default.
- W1978897589 cites W2076763656 @default.
- W1978897589 cites W2086472401 @default.
- W1978897589 cites W2090481553 @default.
- W1978897589 cites W2098671999 @default.
- W1978897589 cites W2100827722 @default.
- W1978897589 cites W2104910525 @default.
- W1978897589 cites W2106510584 @default.
- W1978897589 cites W2115277104 @default.
- W1978897589 cites W2120891749 @default.
- W1978897589 cites W2123006460 @default.
- W1978897589 cites W2126503033 @default.
- W1978897589 cites W2127136381 @default.
- W1978897589 cites W2132182183 @default.
- W1978897589 cites W2134204376 @default.
- W1978897589 cites W2134443084 @default.
- W1978897589 cites W2136590857 @default.
- W1978897589 cites W2137157133 @default.
- W1978897589 cites W2140649712 @default.
- W1978897589 cites W2141449280 @default.
- W1978897589 cites W2143758501 @default.
- W1978897589 cites W2147038697 @default.
- W1978897589 cites W2148753352 @default.
- W1978897589 cites W2162656620 @default.
- W1978897589 cites W2886978647 @default.
- W1978897589 cites W4251633039 @default.
- W1978897589 cites W4313333769 @default.
- W1978897589 doi "https://doi.org/10.1002/eji.200425403" @default.
- W1978897589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15384042" @default.
- W1978897589 hasPublicationYear "2004" @default.
- W1978897589 type Work @default.
- W1978897589 sameAs 1978897589 @default.
- W1978897589 citedByCount "125" @default.
- W1978897589 countsByYear W19788975892012 @default.
- W1978897589 countsByYear W19788975892013 @default.
- W1978897589 countsByYear W19788975892014 @default.
- W1978897589 countsByYear W19788975892015 @default.
- W1978897589 countsByYear W19788975892016 @default.
- W1978897589 countsByYear W19788975892017 @default.
- W1978897589 countsByYear W19788975892018 @default.
- W1978897589 countsByYear W19788975892019 @default.
- W1978897589 countsByYear W19788975892020 @default.
- W1978897589 countsByYear W19788975892021 @default.
- W1978897589 countsByYear W19788975892022 @default.
- W1978897589 countsByYear W19788975892023 @default.
- W1978897589 crossrefType "journal-article" @default.
- W1978897589 hasAuthorship W1978897589A5017271872 @default.
- W1978897589 hasAuthorship W1978897589A5027010008 @default.
- W1978897589 hasAuthorship W1978897589A5033100102 @default.
- W1978897589 hasAuthorship W1978897589A5050963939 @default.
- W1978897589 hasAuthorship W1978897589A5059026139 @default.
- W1978897589 hasAuthorship W1978897589A5064498653 @default.
- W1978897589 hasAuthorship W1978897589A5084920681 @default.
- W1978897589 hasBestOaLocation W19788975891 @default.
- W1978897589 hasConcept C100701293 @default.
- W1978897589 hasConcept C104317684 @default.
- W1978897589 hasConcept C105580179 @default.
- W1978897589 hasConcept C127716648 @default.
- W1978897589 hasConcept C147483822 @default.
- W1978897589 hasConcept C151730666 @default.
- W1978897589 hasConcept C153911025 @default.
- W1978897589 hasConcept C191732599 @default.
- W1978897589 hasConcept C2778690821 @default.