Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978904158> ?p ?o ?g. }
- W1978904158 endingPage "1194" @default.
- W1978904158 startingPage "1187" @default.
- W1978904158 abstract ": Intractable bone pain secondary to bone metastasis from prostate, lung, breast, and other malignancies is a major problem in the management of the oncological patient. Because a number of factors are implicated in the pathophysiology of bone pain, a multidisciplinary approach in its assessment and treatment is often required. Treatment often includes the use of analgesic drug therapy; however, radiation therapy, hormonal therapy, chemotherapy, and surgery may also be needed. : The use of systemic radionuclide therapy may often be helpful to relieve bone pain and improve the quality of life. In the setting of diffuse bone metastasis, intractable to conventional therapy, various radioisotopes have been advocated. These include phosphorous-32, iodine-131, strontium-89, yttrium-90, samarium-153, and rhenium-186, often as either the anionic phosphate or as a ligand (HEDP, EDTMP). : When these agents are used, pain relief often occurs in approximately 2–4 weeks and lasts several weeks to months with responses seen in 60–80% of patients, depending on the extent of disease and stage the patient is treated. Retreatment has been possible in certain cases with further palliation being offered and improvement in the various quality of life parameters being noted. : Myelotoxicity has been a limiting factor with certain isotopes and has led to the development of less toxic bone seeking agents. Although these each have unique physical and biokinetic properties requiring different doses and protocols for administration, they all appear to localize in osteoblastic metastatic sites in sufficient amounts to provide bone pain palliation." @default.
- W1978904158 created "2016-06-24" @default.
- W1978904158 creator A5027342903 @default.
- W1978904158 date "1994-12-01" @default.
- W1978904158 modified "2023-09-25" @default.
- W1978904158 title "Current status of systemic intravenous radiopharmaceuticals for the treatment of painful metastatic bone disease" @default.
- W1978904158 cites W1920947400 @default.
- W1978904158 cites W1963635251 @default.
- W1978904158 cites W1967568802 @default.
- W1978904158 cites W1970629490 @default.
- W1978904158 cites W1976921836 @default.
- W1978904158 cites W1983514189 @default.
- W1978904158 cites W1988369394 @default.
- W1978904158 cites W1990146631 @default.
- W1978904158 cites W1990718568 @default.
- W1978904158 cites W1995975133 @default.
- W1978904158 cites W1999978652 @default.
- W1978904158 cites W2004590041 @default.
- W1978904158 cites W2006734418 @default.
- W1978904158 cites W2017735814 @default.
- W1978904158 cites W2018455116 @default.
- W1978904158 cites W2019023598 @default.
- W1978904158 cites W2019298848 @default.
- W1978904158 cites W2023853369 @default.
- W1978904158 cites W2033952205 @default.
- W1978904158 cites W2043281854 @default.
- W1978904158 cites W2047842438 @default.
- W1978904158 cites W2050664130 @default.
- W1978904158 cites W2054351138 @default.
- W1978904158 cites W2057383698 @default.
- W1978904158 cites W2058815142 @default.
- W1978904158 cites W2059342531 @default.
- W1978904158 cites W2062271329 @default.
- W1978904158 cites W2066860165 @default.
- W1978904158 cites W2068775401 @default.
- W1978904158 cites W2070408871 @default.
- W1978904158 cites W2092389226 @default.
- W1978904158 cites W2097984654 @default.
- W1978904158 cites W2103227635 @default.
- W1978904158 cites W2130484646 @default.
- W1978904158 cites W2139809746 @default.
- W1978904158 cites W2142814605 @default.
- W1978904158 cites W2156722174 @default.
- W1978904158 cites W2333551928 @default.
- W1978904158 cites W2401802839 @default.
- W1978904158 cites W2415481317 @default.
- W1978904158 cites W2429954146 @default.
- W1978904158 doi "https://doi.org/10.1016/0360-3016(94)90327-1" @default.
- W1978904158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7525518" @default.
- W1978904158 hasPublicationYear "1994" @default.
- W1978904158 type Work @default.
- W1978904158 sameAs 1978904158 @default.
- W1978904158 citedByCount "61" @default.
- W1978904158 countsByYear W19789041582012 @default.
- W1978904158 countsByYear W19789041582015 @default.
- W1978904158 countsByYear W19789041582016 @default.
- W1978904158 countsByYear W19789041582018 @default.
- W1978904158 countsByYear W19789041582020 @default.
- W1978904158 countsByYear W19789041582022 @default.
- W1978904158 crossrefType "journal-article" @default.
- W1978904158 hasAuthorship W1978904158A5027342903 @default.
- W1978904158 hasConcept C121608353 @default.
- W1978904158 hasConcept C126322002 @default.
- W1978904158 hasConcept C141071460 @default.
- W1978904158 hasConcept C2776139714 @default.
- W1978904158 hasConcept C2776169692 @default.
- W1978904158 hasConcept C2776541429 @default.
- W1978904158 hasConcept C2776694085 @default.
- W1978904158 hasConcept C2777783956 @default.
- W1978904158 hasConcept C2779013556 @default.
- W1978904158 hasConcept C2993559085 @default.
- W1978904158 hasConcept C509974204 @default.
- W1978904158 hasConcept C71924100 @default.
- W1978904158 hasConceptScore W1978904158C121608353 @default.
- W1978904158 hasConceptScore W1978904158C126322002 @default.
- W1978904158 hasConceptScore W1978904158C141071460 @default.
- W1978904158 hasConceptScore W1978904158C2776139714 @default.
- W1978904158 hasConceptScore W1978904158C2776169692 @default.
- W1978904158 hasConceptScore W1978904158C2776541429 @default.
- W1978904158 hasConceptScore W1978904158C2776694085 @default.
- W1978904158 hasConceptScore W1978904158C2777783956 @default.
- W1978904158 hasConceptScore W1978904158C2779013556 @default.
- W1978904158 hasConceptScore W1978904158C2993559085 @default.
- W1978904158 hasConceptScore W1978904158C509974204 @default.
- W1978904158 hasConceptScore W1978904158C71924100 @default.
- W1978904158 hasIssue "5" @default.
- W1978904158 hasLocation W19789041581 @default.
- W1978904158 hasLocation W19789041582 @default.
- W1978904158 hasOpenAccess W1978904158 @default.
- W1978904158 hasPrimaryLocation W19789041581 @default.
- W1978904158 hasRelatedWork W1978904158 @default.
- W1978904158 hasRelatedWork W2004114771 @default.
- W1978904158 hasRelatedWork W2077101439 @default.
- W1978904158 hasRelatedWork W2109360630 @default.
- W1978904158 hasRelatedWork W2146453592 @default.
- W1978904158 hasRelatedWork W2317793619 @default.
- W1978904158 hasRelatedWork W4210964201 @default.
- W1978904158 hasRelatedWork W4226317989 @default.