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• W1978904584 abstract "Based on computer modeling of the active site of nitric oxide synthases (NOS), a series of 10 amidine compounds (9-18) was designed including potential inhibitors that involve the coordination of side-chain functional groups with the iron of the heme cofactor. The most potent and selective compound was the methylthio amidine analogue 9, which was more potent than L-nitroarginine with 185-fold selectivity for inhibition of neuronal NOS over endothelial NOS. It also exhibited time-dependent inhibition, but did not involve the mechanism previously proposed for other amidine inhibitors of NOS. None of the compounds, however, exhibited heme-binding characteristics according to absorption spectroscopy." @default.
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• W1978904584 date "2006-05-01" @default.
• W1978904584 modified "2023-09-23" @default.
• W1978904584 title "Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors" @default.
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• W1978904584 doi "https://doi.org/10.1016/j.bmc.2005.12.043" @default.
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