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- W1978920257 abstract "Piracetam is a cyclic derivative of γ-aminobutyric acid (GABA). It was the first nootropic drug approved for clinical use. However, mechanism of its action is still not clear. In present paper, I investigated effects of piracetam on neurotransmitter release, plasma membrane potential monitored by fluorescent dye DiSC3(5) and chloride transport monitored by fluorescent dye SPQ in rat brain synaptosomes. It was shown that piracetam (1 mM) induces slow weak plasma membrane depolarization. This effect was decreased on 43% and 58% by both AMPA/kainate receptor blockers NBQX (10 μM) and CNQX (100 μM), respectively, on 84% by GABA ionotropic receptor blocker picrotoxin (50 μM) and on 91% upon withdrawal of HCO3− ions from incubation medium. GABA (1 mM) and kainate (100 μM) were found not to produce changes of plasma membrane potential. Also, it was found that piracetam induces chloride efflux which seems to be the reason of depolarization. Thereby, piracetam induces depolarization of plasma membrane of isolated neuronal presynaptic endings by picrotoxin-sensitive way." @default.
- W1978920257 created "2016-06-24" @default.
- W1978920257 creator A5069325826 @default.
- W1978920257 date "2013-10-01" @default.
- W1978920257 modified "2023-10-16" @default.
- W1978920257 title "Piracetam induces plasma membrane depolarization in rat brain synaptosomes" @default.
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- W1978920257 doi "https://doi.org/10.1016/j.neulet.2013.08.045" @default.
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