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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978921288> ?p ?o ?g. }

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• W1978921288 abstract "The discovery of highly potent and selective second generation EP(4) antagonist MK-2894 (34d) is discussed. This compound exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. It also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin." @default.
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• W1978921288 date "2010-02-17" @default.
• W1978921288 modified "2023-09-23" @default.
• W1978921288 title "The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E₂ Subtype 4 Receptor Antagonist" @default.
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• W1978921288 doi "https://doi.org/10.1021/jm901771h" @default.
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