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• W1978943655 abstract "The paper reports on a comparative evaluation of 10 rapid malaria tests available in South Africa in 1998: AccuCheck (AC, developmental), Cape Biotech (CB), ICT Malaria Pf (ICT1) and Pf/Pv (ICT2), Kat Medical (KAT), MakroMal (MM), OptiMAL (OP), ParaSight-F (PS), Quorum (Q), Determine-Malaria (DM). In a laboratory study, designed to test absolute detection limits, Plasmodium falciparum-infected blood was diluted with uninfected blood to known parasite concentrations ranging from 500 to 0·1 parasites per microlitre (P/μL). The 50% detection limits were: ICT1, 3·28; ICT2, 4·86; KAT, 6·36; MM, 9·37; CB, 11·42; DM, 12·40; Q, 16·98; PS, 20; AC, 31·15 and OP, 91·16 P/μL. A field study was carried out to test post-treatment specificity. Blood samples from malaria patients were tested with all products (except AC and DM) on the day of treatment and 3 and 7 days thereafter, against a gold standard of microscopy and polymerase chain reaction (PCR). OP and PS produced fewer false-positive results on day 7 (18 and 19%, respectively) than the other rapid tests (38–56%). However, microscopy, PCR, OP and PS disagreed largely as to which individuals remained positive. The tests were further compared with regard to general specificity, particularly cross-reactivity with rheumatoid factor, speed, simplicity, their ability to detect other species, storage requirements and general presentation." @default.
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• W1978943655 date "2002-05-01" @default.
• W1978943655 modified "2023-10-15" @default.
• W1978943655 title "Field and laboratory comparative evaluation of ten rapid malaria diagnostic tests" @default.
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• W1978943655 doi "https://doi.org/10.1016/s0035-9203(02)90092-1" @default.
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