Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978946543> ?p ?o ?g. }
- W1978946543 endingPage "13" @default.
- W1978946543 startingPage "1" @default.
- W1978946543 abstract "S100B promotes development and maturation in the mammalian brain. However, prolonged or extensive exposure can lead to neurodegeneration. Two important functions of S100B in this regard, are its role in the development and plasticity of the serotonergic neurotransmitter system, and its role in the cascade of glial changes associated with neuroinflammation. Both of these processes are therefore accelerated towards degeneration in disease processes wherein S100B is increased, notably, Alzheimer's disease (AD) and Down syndrome (DS). In order to study the role of S100B in this context, we have examined S100B overexpressing transgenic mice. Similar to AD and DS, the transgenic animals show a profound change in serotonin innervation. By 28 weeks of age, there is a significant loss of terminals in the hippocampus. Similarly, the transgenic animals show neuroinflammatory changes analogous with AD and DS. These include decreased numbers of mature, stable astroglial cells, increased numbers of activated microglial cells and increased microglial expression of the cell surface receptor RAGE. Eventually, the S100B transgenic animals show neurodegeneration and the appearance of hyperphosphorylated tau structures, as seen in late stage DS and AD. The role of S100B in these conditions is discussed." @default.
- W1978946543 created "2016-06-24" @default.
- W1978946543 creator A5045645414 @default.
- W1978946543 creator A5054008082 @default.
- W1978946543 creator A5069253641 @default.
- W1978946543 date "2010-08-22" @default.
- W1978946543 modified "2023-09-27" @default.
- W1978946543 title "Effects of S100B on Serotonergic Plasticity and Neuroinflammation in the Hippocampus in Down Syndrome and Alzheimer's Disease: Studies in an S100B Overexpressing Mouse Model" @default.
- W1978946543 cites W1503258737 @default.
- W1978946543 cites W1563590122 @default.
- W1978946543 cites W158119579 @default.
- W1978946543 cites W1812789667 @default.
- W1978946543 cites W1828538530 @default.
- W1978946543 cites W1908113228 @default.
- W1978946543 cites W1951010197 @default.
- W1978946543 cites W1963583887 @default.
- W1978946543 cites W1964713959 @default.
- W1978946543 cites W1965055828 @default.
- W1978946543 cites W1968241031 @default.
- W1978946543 cites W1970468452 @default.
- W1978946543 cites W1972637602 @default.
- W1978946543 cites W1974803491 @default.
- W1978946543 cites W1977604451 @default.
- W1978946543 cites W1980328024 @default.
- W1978946543 cites W1984331201 @default.
- W1978946543 cites W1986229796 @default.
- W1978946543 cites W1992720785 @default.
- W1978946543 cites W1993553563 @default.
- W1978946543 cites W1993942559 @default.
- W1978946543 cites W1996719475 @default.
- W1978946543 cites W1997507890 @default.
- W1978946543 cites W1997869951 @default.
- W1978946543 cites W1998826717 @default.
- W1978946543 cites W1999330418 @default.
- W1978946543 cites W2002613500 @default.
- W1978946543 cites W2003674452 @default.
- W1978946543 cites W2003744669 @default.
- W1978946543 cites W2003789023 @default.
- W1978946543 cites W2009889157 @default.
- W1978946543 cites W2012505933 @default.
- W1978946543 cites W2012741273 @default.
- W1978946543 cites W2012997306 @default.
- W1978946543 cites W2013933538 @default.
- W1978946543 cites W2014988222 @default.
- W1978946543 cites W2018526785 @default.
- W1978946543 cites W2018922793 @default.
- W1978946543 cites W2020359241 @default.
- W1978946543 cites W2023586735 @default.
- W1978946543 cites W2032947269 @default.
- W1978946543 cites W2033347794 @default.
- W1978946543 cites W2036091553 @default.
- W1978946543 cites W2037366132 @default.
- W1978946543 cites W2038036111 @default.
- W1978946543 cites W2040794248 @default.
- W1978946543 cites W2041238959 @default.
- W1978946543 cites W2041986966 @default.
- W1978946543 cites W2042676032 @default.
- W1978946543 cites W2042735193 @default.
- W1978946543 cites W2043442200 @default.
- W1978946543 cites W2043555322 @default.
- W1978946543 cites W2044440168 @default.
- W1978946543 cites W2045283840 @default.
- W1978946543 cites W2045378863 @default.
- W1978946543 cites W2048308101 @default.
- W1978946543 cites W2050712966 @default.
- W1978946543 cites W2052087357 @default.
- W1978946543 cites W2055316677 @default.
- W1978946543 cites W2063249182 @default.
- W1978946543 cites W2065140692 @default.
- W1978946543 cites W2065419688 @default.
- W1978946543 cites W2065633430 @default.
- W1978946543 cites W2065656296 @default.
- W1978946543 cites W2066858262 @default.
- W1978946543 cites W2068384471 @default.
- W1978946543 cites W2071695496 @default.
- W1978946543 cites W2075763119 @default.
- W1978946543 cites W2083082012 @default.
- W1978946543 cites W2083652796 @default.
- W1978946543 cites W2085224800 @default.
- W1978946543 cites W2086423038 @default.
- W1978946543 cites W2086712398 @default.
- W1978946543 cites W2089856175 @default.
- W1978946543 cites W2090336391 @default.
- W1978946543 cites W2090930997 @default.
- W1978946543 cites W2091826796 @default.
- W1978946543 cites W2092665983 @default.
- W1978946543 cites W2094286956 @default.
- W1978946543 cites W2094867378 @default.
- W1978946543 cites W2095203539 @default.
- W1978946543 cites W2102935355 @default.
- W1978946543 cites W2105900044 @default.
- W1978946543 cites W2107013935 @default.
- W1978946543 cites W2114150652 @default.
- W1978946543 cites W2122946630 @default.
- W1978946543 cites W2124080310 @default.
- W1978946543 cites W2129771435 @default.
- W1978946543 cites W2130914256 @default.
- W1978946543 cites W2138554096 @default.