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- W1978948610 abstract "ABSTRACT This study was for the investigation of the stability of purified bee venom (PBV) during the treatment in the pH rangefrom pH2 to pH9 for 24 hours, respectively. Changes of components and physiological functionalities in PBV were byevaluated silver staining, and melittin contents were measured by liquid chromatography. The antimicrobial activityagainst bacteria by minimum inhibitory concentration (MIC) and effect of the cell regeneration were measured by 3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl tetrazolium bromide (MTT) assay using human dermal fibroblast (HDF) cell.The main proteins such as melittin and phospholipase A 2 showed no characteristic changes. The antimicrobial activityand effect of cell regeneration showed no difference from pH2 to pH9. From this study, we suggest that componentsand physiological functionalities of PBV against treated pH were kept stability at from pH2 to pH9.Key words : Apis mellifera, Bee venom, Component, pH 서론 봉독은 꿀벌(Apis mellifera L.)의 독낭에 들어있는 자기방어 물질로 봉침은 수천년 전부터 관절염, 통풍 등(Kimet al. 2002, Kim et al. 2003) 치료에 한방과 민간요법으로 이용되어 왔다(Kim 1992). 봉독은 40여 가지의 성분으로이루어져 있으며, peptide 성분으로는 melittin, apamin, mastcell degranulating(MCD) peptide 등이 있으며, 효소 성분으로는 phospholipase A" @default.
- W1978948610 created "2016-06-24" @default.
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- W1978948610 date "2014-04-30" @default.
- W1978948610 modified "2023-09-26" @default.
- W1978948610 title "Stability of main components and physiological activities of bee venom treated with pH" @default.
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- W1978948610 doi "https://doi.org/10.7852/jses.2014.52.1.6" @default.
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