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• W1978951858 abstract "You have accessJournal of UrologyImaging/Radiology: Uroradiology1 Apr 20112310 USEFULNESS OF CONTRAST-ENHANCED ULTRASOUND USING A TIME- INTENSITY CURVE FOR THE DIAGNOSIS OF CYSTIC RENAL CELL CARCINOMA Shigeyuki Aoki, Genya Nishikawa, Takahiko Yoshizawa, Yoshiharu Kato, Kenji Zennami, Motoi Tobiume, Kogenta Nakamura, Yoshiaki Yamada, Nobuaki Honda, Tokunori Yamamoto, Rhohei Hattori, and Momokazu Gotoh Shigeyuki AokiShigeyuki Aoki Aichi, Japan More articles by this author , Genya NishikawaGenya Nishikawa Aichi, Japan More articles by this author , Takahiko YoshizawaTakahiko Yoshizawa Aichi, Japan More articles by this author , Yoshiharu KatoYoshiharu Kato Aichi, Japan More articles by this author , Kenji ZennamiKenji Zennami Aichi, Japan More articles by this author , Motoi TobiumeMotoi Tobiume Aichi, Japan More articles by this author , Kogenta NakamuraKogenta Nakamura Aichi, Japan More articles by this author , Yoshiaki YamadaYoshiaki Yamada Aichi, Japan More articles by this author , Nobuaki HondaNobuaki Honda Aichi, Japan More articles by this author , Tokunori YamamotoTokunori Yamamoto Nagoya, Japan More articles by this author , Rhohei HattoriRhohei Hattori Nagoya, Japan More articles by this author , and Momokazu GotohMomokazu Gotoh Nagoya, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2556AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES On imaging differentiation, cystic renal cell carcinoma remains a common and difficult diagnostic problem. We assessed the usefulness of contrast-enhanced ultrasound (CEUS) for the diagnosis of cystic renal cell carcinoma by using a time-intensity curve. METHODS CEUS was performed in 30 patients, who had renal masses detected by ultrasound (US) or computed tomography (CT). In all, 10 of the 30 patients had cystic renal masses. The CT images were assessed using the Bosniak classification. The 10 cystic renal masses were categorized by CT as follows: Bosniak category IIF (n=2), category III (n=3) and category IV (n=5). The final diagnosis of all patients was pathologically confirmed using tissue specimens obtained from radical or partial nephrectomy. CEUS was performed prior to surgery using high-resolution US units (LOGIQ 7 [GE Medical Systems; Milwaukee, WI, USA]) equipped with hybrid contrast imaging. The US contrast agent perflubutane (Sonazoid®,Daiichi-Sankyo, Tokyo, Japan) was intravenously administered by bolus injection (0.015ml/kg). To reduce microbubble destruction, a low mechanical index (0.4) was used. Real-time scanning commenced immediately after the injection of the contrast agent. Contrast enhancement as a function of time was measured in two (tumor or solid component of cystic lesions and normal parenchyma) circular regions of interest (ROI) and time-intensity curves were obtained. The time to the contrast enhancement peak (TTP), intensity change from the baseline to peak (ΔI), and ΔI / TTP of the tumor and the normal parenchyma were measured from the time-intensity curve and compared statistically. RESULTS The pathologic diagnosis were renal cell carcinoma in 30 patients. In subgroups of patients with solid and cystic tumors, the TTP of the tumor was significantly shorter than that of the normal parenchyma in all cases (mean seconds [s] ±SD: 5.8±1.6 vs. 10.0±2.9; p<0.0001). There was no ΔI difference between the tumor and normal parenchyma (mean decibels [db] ±SD: 22.3±6.0 vs. 20.5±7.2; p=0.68); the ΔI / TTP of the tumor was significantly higher than that of the normal parenchyma (mean db/s±SD: 4.1±1.4 vs. 2.2±1.1; p<0.0001). The time-intensity curve patterns of solid and cystic cancers were very similar. CEUS demonstrated a well-enhancing mural nodule within the lesion in two cystic tumors diagnosed as Bosniak category IIF. CONCLUSIONS Contrast-enhanced ultrasound using a time-intensity curve is a promising tool in the diagnosis of cystic renal cell carcinoma. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e926 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shigeyuki Aoki Aichi, Japan More articles by this author Genya Nishikawa Aichi, Japan More articles by this author Takahiko Yoshizawa Aichi, Japan More articles by this author Yoshiharu Kato Aichi, Japan More articles by this author Kenji Zennami Aichi, Japan More articles by this author Motoi Tobiume Aichi, Japan More articles by this author Kogenta Nakamura Aichi, Japan More articles by this author Yoshiaki Yamada Aichi, Japan More articles by this author Nobuaki Honda Aichi, Japan More articles by this author Tokunori Yamamoto Nagoya, Japan More articles by this author Rhohei Hattori Nagoya, Japan More articles by this author Momokazu Gotoh Nagoya, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W1978951858 title "2310 USEFULNESS OF CONTRAST-ENHANCED ULTRASOUND USING A TIME- INTENSITY CURVE FOR THE DIAGNOSIS OF CYSTIC RENAL CELL CARCINOMA" @default.
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