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- W1978953318 endingPage "4006" @default.
- W1978953318 startingPage "3987" @default.
- W1978953318 abstract "The goal of this review is to highlight the wide range of biological activities displayed by purines, with particular emphasis on new purine-based agents which find potential application as chemical-biology tools and/or therapeutic agents. The expanding interest in the biological properties of polyfunctionalized purine derivatives issues, in large part, from the development of rapid high-throughput screening essays for new protein targets, and the corresponding development of efficient synthetic methodology adapted to the construction of highly diverse purine libraries. Purine-based compounds have found new applications as inducers of interferon and lineage-committed cell dedifferentiation, agonists and antagonists of adenosine receptors, ligands of corticotropin-releasing hormone receptors, and as inhibitors of HSP90, Src kinase, p38α MAP kinase, sulfotransferases, phosphodiesterases, and Cdks. The scope of application of purines in biology is most certainly far from being exhausted. Testing purine derivatives against the multitude of biological targets for which small molecule probes have not yet been found should thus be a natural reflex." @default.
- W1978953318 created "2016-06-24" @default.
- W1978953318 creator A5004043219 @default.
- W1978953318 creator A5039223178 @default.
- W1978953318 date "2006-06-01" @default.
- W1978953318 modified "2023-10-18" @default.
- W1978953318 title "The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets" @default.
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