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- W1978955028 abstract "The kinetics of the R and S epimers of moxalactam were followed after single intravenous doses of 50 mg/kg to 12 patients, 8 to 45 mo old, with cellulitis or epiglottitis. High-pressure liquid chromatography was used to determine serum concentrations. Total body clearance and apparent volume of distribution of the R epimer were higher than those of the S epimer (P less than 0.004). Total body clearance of R, S, and R + S moxalactam ranged from 29.01 to 183.7, 19.00 to 79.95, and 23.34 to 113.6 ml/min/m2. Mean elimination half-lives of R, S, and R + X moxalactam were 2.04, 2.26, and 2.24 hr. The higher incidence of the more active R epimer and the 500% interpatient variation in clearance may indicate a need for monitoring serum and cerebrospinal fluid concentrations in patients with severe unresponsive central nervous system infectious treated with moxalactam." @default.
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- W1978955028 date "1982-04-01" @default.
- W1978955028 modified "2023-09-25" @default.
- W1978955028 title "Moxalactam epimer kinetics in children" @default.
- W1978955028 doi "https://doi.org/10.1038/clpt.1982.71" @default.
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- W1978955028 hasPublicationYear "1982" @default.
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