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• W1978956721 abstract "Interleukins (IL) are part of the group of immunemediators known as cytokines. IL are produced by manydifferent cells and possess a wide spectrum of biologicalactivities. This review will be focused on the role of IL-1to 6, 8, 10-13 as it pertains to the effects of hyperoxia onthe adult and newborn lung in animal models. Hyperoxicexposure to the adult and newborn lung had variable effectson the expression of IL-1α and IL-1β. Increased IL-6levels were seen in adult lungs by day 3 and in the newbornlungs by day 10 of exposure to hyperoxia. IL-8 alsopeaked around day 10 in the newborn lung but there wereno significant changes in IL-10. Pretreatment with IL-1,endotoxin, rhSOD, lidocaine, lisofylline, pentoxifylline andoverexpression of IL-6, 11, and 13 seemed to attenuatehyperoxic lung injury in the adult. This protection wasaccompanied by increased pulmonary MnSOD, VEGFexpression and decreased apoptosis.It is clear that IL have a significant role to play inhyperoxic lung injury. Increased IL expression and releasehas a cascade effect and appears to predate the influx ofinflammatory cells. There are significant differences in thetype and timing of IL expression and release in the adultand newborn lung in response to hyperoxia. Designing atherapeutic approach to counteract oxygen toxicity in theimmature lung first needs understanding of the uniqueresponses in the newborn." @default.
• W1978956721 created "2016-06-24" @default.
• W1978956721 creator A5049642684 @default.
• W1978956721 date "2002-01-01" @default.
• W1978956721 modified "2023-09-22" @default.
• W1978956721 title "Developmental differences in the role of interleukins in hyperoxic lung injury in animal models" @default.
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• W1978956721 doi "https://doi.org/10.2741/a866" @default.
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