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- W1978956991 abstract "Basic fibroblast growth factor (bFGF) is overexpressed in most high-grade human gliomas, implying that it is involved in the pathogenesis of these tumors. To assess the biological effect of inappropriate production of bFGF in normal astrocytes, we developed a system for glia-specific gene transfer in transgenic mice. A transgene encoding the receptor for subgroup A avian leukosis virus and controlled by the astrocyte-specific glial fibrillary acidic protein promoter permits efficient glia-specific transfer of genes carried by subgroup A avian leukosis virus vectors. With this system, we have demonstrated that bFGF induces proliferation and migration of glial cells in vivo, without the induction of tumors." @default.
- W1978956991 created "2016-06-24" @default.
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- W1978956991 date "1998-02-03" @default.
- W1978956991 modified "2023-10-09" @default.
- W1978956991 title "Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice" @default.
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- W1978956991 doi "https://doi.org/10.1073/pnas.95.3.1218" @default.
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