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- W1978958888 abstract "<h3>Objective:</h3> Spontaneous recovery of a sixth nerve palsy is thought to rule out a neoplastic origin. We reviewed cases of sixth nerve palsy that improved without treatment but that ultimately proved to be caused by a tumor at the base of the skull. <h3>Design:</h3> Case series. <h3>Setting:</h3> Hospital-based, neuro-ophthalmology referral practice. <h3>Patients:</h3> Seven patients with an age range from 7 to 61 years had sixth nerve palsy secondary to a slow-growing neoplasm at the skull base. <h3>Main Outcome Measures:</h3> Return of lateral rectus function and resolution of diplopia without intervention. <h3>Results:</h3> Seven patients with sixth nerve palsy caused by skull base tumors experienced spontaneous improvement of their deficit. Recovery time ranged from 1 week to 18 months. No patient was diabetic or had evidence of vascular disease. In one patient, the palsy improved once prior to becoming a fixed deficit, and spontaneous improvement occurred on two to five occasions in the other patients. <h3>Conclusion:</h3> Spontaneous recovery of a sixth nerve palsy can occur in the presence of an extramedullary compression by a tumor at the base of the brain. Possible mechanisms for recovery include remyelination, axonal regeneration, relief of transient compression (eg, resorption of hemorrhage), restoration of impaired blood flow, slippage of a nerve previously stretched over the tumor, or immune responses to the tumor." @default.
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- W1978958888 date "1993-10-01" @default.
- W1978958888 modified "2023-10-11" @default.
- W1978958888 title "Remitting Sixth Nerve Palsy in Skull Base Tumors" @default.
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- W1978958888 doi "https://doi.org/10.1001/archopht.1993.01090100099035" @default.
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