Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978962308> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1978962308 endingPage "1626" @default.
- W1978962308 startingPage "1618" @default.
- W1978962308 abstract "The primary transcript of the calcitonin (CT)/calcitonin gene-related peptide (CGRP) is alternatively spliced in a cell-specific fashion to produce CT in thyroid C cells and CGRP in neuronal cells. The key step in this regulatory process is the recognition and inclusion of exon 4 to produce CT mRNA or nonrecognition and exclusion of exon 4 to produce CGRP mRNA. To determine whether inclusion/exclusion of CT exon is regulated independently of its position, we created a series of minigene constructs containing decreasing amounts of CT gene sequence. A human glioblastoma cell line, T98G, was tested and used as a CT exon exclusion cell line, while HeLa cells were used as a CT exon inclusion cell line. CT exon inclusion/exclusion was regulated when either the relative position of exon 4 within the CT gene was changed or when the exon with flanking sequence was inserted into a completely heterologous gene. Our results demonstrate that CT exon functions as a unit in a position-independent fashion in regulating its own inclusion/exclusion. We believe that the heterologous fusion gene containing only exon 4 and part of its flanking intron sequences will be useful for further defining the sequence elements involved in the regulation of CT/CGRP splicing." @default.
- W1978962308 created "2016-06-24" @default.
- W1978962308 creator A5026248910 @default.
- W1978962308 creator A5046671975 @default.
- W1978962308 creator A5071941800 @default.
- W1978962308 date "1994-12-01" @default.
- W1978962308 modified "2023-09-27" @default.
- W1978962308 title "The calcitonin exon and its flanking intronic sequences are sufficient for the regulation of human calcitonin/calcitonin gene-related peptide alternative RNA splicing." @default.
- W1978962308 cites W1557189154 @default.
- W1978962308 cites W1965208181 @default.
- W1978962308 cites W1973423530 @default.
- W1978962308 cites W1980299957 @default.
- W1978962308 cites W1981956038 @default.
- W1978962308 cites W1993243592 @default.
- W1978962308 cites W2031130109 @default.
- W1978962308 cites W2035961932 @default.
- W1978962308 cites W2036228528 @default.
- W1978962308 cites W2051070103 @default.
- W1978962308 cites W2071740248 @default.
- W1978962308 cites W2071971601 @default.
- W1978962308 cites W2076944748 @default.
- W1978962308 cites W2081201806 @default.
- W1978962308 cites W2149563853 @default.
- W1978962308 cites W2152848856 @default.
- W1978962308 cites W2170266703 @default.
- W1978962308 doi "https://doi.org/10.1210/mend.8.12.7535892" @default.
- W1978962308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7535892" @default.
- W1978962308 hasPublicationYear "1994" @default.
- W1978962308 type Work @default.
- W1978962308 sameAs 1978962308 @default.
- W1978962308 citedByCount "14" @default.
- W1978962308 countsByYear W19789623082013 @default.
- W1978962308 countsByYear W19789623082017 @default.
- W1978962308 countsByYear W19789623082018 @default.
- W1978962308 crossrefType "journal-article" @default.
- W1978962308 hasAuthorship W1978962308A5026248910 @default.
- W1978962308 hasAuthorship W1978962308A5046671975 @default.
- W1978962308 hasAuthorship W1978962308A5071941800 @default.
- W1978962308 hasBestOaLocation W19789623081 @default.
- W1978962308 hasConcept C104317684 @default.
- W1978962308 hasConcept C118303440 @default.
- W1978962308 hasConcept C134018914 @default.
- W1978962308 hasConcept C153911025 @default.
- W1978962308 hasConcept C163170386 @default.
- W1978962308 hasConcept C166342232 @default.
- W1978962308 hasConcept C170493617 @default.
- W1978962308 hasConcept C190017056 @default.
- W1978962308 hasConcept C194583182 @default.
- W1978962308 hasConcept C2779627488 @default.
- W1978962308 hasConcept C36823959 @default.
- W1978962308 hasConcept C39917842 @default.
- W1978962308 hasConcept C54355233 @default.
- W1978962308 hasConcept C54458228 @default.
- W1978962308 hasConcept C67705224 @default.
- W1978962308 hasConcept C86803240 @default.
- W1978962308 hasConcept C94671646 @default.
- W1978962308 hasConceptScore W1978962308C104317684 @default.
- W1978962308 hasConceptScore W1978962308C118303440 @default.
- W1978962308 hasConceptScore W1978962308C134018914 @default.
- W1978962308 hasConceptScore W1978962308C153911025 @default.
- W1978962308 hasConceptScore W1978962308C163170386 @default.
- W1978962308 hasConceptScore W1978962308C166342232 @default.
- W1978962308 hasConceptScore W1978962308C170493617 @default.
- W1978962308 hasConceptScore W1978962308C190017056 @default.
- W1978962308 hasConceptScore W1978962308C194583182 @default.
- W1978962308 hasConceptScore W1978962308C2779627488 @default.
- W1978962308 hasConceptScore W1978962308C36823959 @default.
- W1978962308 hasConceptScore W1978962308C39917842 @default.
- W1978962308 hasConceptScore W1978962308C54355233 @default.
- W1978962308 hasConceptScore W1978962308C54458228 @default.
- W1978962308 hasConceptScore W1978962308C67705224 @default.
- W1978962308 hasConceptScore W1978962308C86803240 @default.
- W1978962308 hasConceptScore W1978962308C94671646 @default.
- W1978962308 hasIssue "12" @default.
- W1978962308 hasLocation W19789623081 @default.
- W1978962308 hasLocation W19789623082 @default.
- W1978962308 hasOpenAccess W1978962308 @default.
- W1978962308 hasPrimaryLocation W19789623081 @default.
- W1978962308 hasRelatedWork W1926883706 @default.
- W1978962308 hasRelatedWork W1978962308 @default.
- W1978962308 hasRelatedWork W2059027168 @default.
- W1978962308 hasRelatedWork W2099508751 @default.
- W1978962308 hasRelatedWork W2136735424 @default.
- W1978962308 hasRelatedWork W2154467209 @default.
- W1978962308 hasRelatedWork W2313404803 @default.
- W1978962308 hasRelatedWork W2796118888 @default.
- W1978962308 hasRelatedWork W4239231391 @default.
- W1978962308 hasRelatedWork W4317937367 @default.
- W1978962308 hasVolume "8" @default.
- W1978962308 isParatext "false" @default.
- W1978962308 isRetracted "false" @default.
- W1978962308 magId "1978962308" @default.
- W1978962308 workType "article" @default.