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- W1978969247 abstract "Alfimeprase is a recombinantly produced, truncated form of fibrolase, a known fibrinolytic zinc metalloproteinase that was first isolated from the venom of Agkistrodon contortrix contortrix, the southern copperhead snake (; ). Fibrolase is a member of clan MB of metallopeptidases, family M12, subfamily B (the reprolysins), a grouping of proteolytic enzymes that are comprised of many enzymes originally characterized from snake venoms (). The active site of the molecule was first described by , who identified that the zinc-binding region of the fibrolase molecule spans amino acids 139–159. The alfimeprase molecule differs slightly from native fibrolase where alfimeprase contains 201 amino acids with an N-terminal sequence of SFPQR—in contrast to fibrolase, which is 203 amino acids in length with an N-terminal sequence that begins with EQRFPQR (). These two enzymes are similar with respect to enzymatic activity." @default.
- W1978969247 created "2016-06-24" @default.
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- W1978969247 date "2006-01-01" @default.
- W1978969247 modified "2023-09-26" @default.
- W1978969247 title "NONCLINICAL AND CLINICAL CHARACTERIZATION OF A NOVEL ACTING THROMBOLYTIC: ALFIMEPRASE" @default.
- W1978969247 cites W2015183661 @default.
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- W1978969247 doi "https://doi.org/10.1080/15569540600567396" @default.
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