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- W1978973485 abstract "Abstract The EDL muscle of the Bar Harbor Strain C57BL 6Jdy 2j mouse was studied in serial section by light and electron microscopy. Phase contrast microscopy of 15 μm epon sections revealed fiber abnormalities such as central nucleation, atypical fiber diameter and regions of focal fiber necrosis; fiber splitting detected in such sections was a prominent feature of the myotonic muscle. Ultrathin resectioning of selected 15 μm sections showed additional alterations such as dilation of the sarcoplasmic reticulum, mitochondrial conglomerations and disruptions, sarcolemmal infolding and breakdown, and myofibrillar degeneration. The most notable neuropathic changes included distortion in shape and decrease in numbers of synaptic vesicles as well as axonal retraction, reduplication of the basement membrane, and the presence of dense bodies between axon and junctional sarcolemma. These data indicate the involvement of both muscle fiber and motor end plate in mouse myotonic dystrophy." @default.
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- W1978973485 date "1974-12-01" @default.
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- W1978973485 title "Myotonic muscle in mouse: A light and electron microscopic study in serial sections" @default.
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- W1978973485 doi "https://doi.org/10.1016/0014-4886(74)90152-6" @default.
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