FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978986554> ?p ?o ?g. }

• W1978986554 endingPage "417" @default.
• W1978986554 startingPage "409" @default.
• W1978986554 abstract "The effects of added phosphate and MgADP on unloaded shortening velocity during maximal and submaximal Ca2+ activation of the thin filament were examined in skinned single skeletal fibers from rabbit psoas muscle. During maximal Ca2+ activation, added phosphate (10-30 mM) had no effect on unloaded shortening velocity as determined by the slack-test technique. In fibers activated at submaximal concentrations of Ca2+ in the absence of added phosphate, plots of slack length versus duration of unloaded shortening were biphasic, consisting of an initial high velocity phase of shortening and a subsequent low velocity phase of shortening. Interestingly, in the presence of added phosphate, biphasic slack-test plots were no longer apparent. This result was obtained in control fibers over a range of submaximal Ca2+ concentrations and in maximally Ca2+ activated fibers, which were first treated to partially extract troponin C. Thus, under conditions that favor the appearance of biphasic shortening (i.e., low [Ca2+], troponin C extraction), added phosphate eliminated the low velocity component. In contrast, in fibers activated in the presence of 5 mM added MgADP, biphasic slack-test plots were apparent even during maximal Ca2+ activation. The basis of biphasic shortening is not known but it may be due to the formation of axially compressed cross-bridges that become strained to bear a tension that opposes the relative sliding of the myofilaments. The present findings could be explained if added phosphate and MgADP bind to cross-bridges in a strain-dependent manner. In this case, the results suggest that phosphate inhibits the formation of cross-bridges that bear a compressive strain. Added MgADP, on the other hand, may be expected to detain cross-bridges in strong binding states, thus promoting an increase in the population of cross-bridges bearing a compressive strain. Alterations in the population of strained cross-bridges by added phosphate and MgADP would alter the internal load within the fiber and thus affect the speed of fiber shortening." @default.
• W1978986554 created "2016-06-24" @default.
• W1978986554 creator A5035642806 @default.
• W1978986554 date "1996-01-01" @default.
• W1978986554 modified "2023-10-18" @default.
• W1978986554 title "Effects of phosphate and ADP on shortening velocity during maximal and submaximal calcium activation of the thin filament in skeletal muscle fibers" @default.
• W1978986554 cites W1156084614 @default.
• W1978986554 cites W1499122117 @default.
• W1978986554 cites W1546003942 @default.
• W1978986554 cites W1566481288 @default.
• W1978986554 cites W1578284467 @default.
• W1978986554 cites W1967108244 @default.
• W1978986554 cites W1971274190 @default.
• W1978986554 cites W1980685237 @default.
• W1978986554 cites W1989255509 @default.
• W1978986554 cites W1998635013 @default.
• W1978986554 cites W2002527385 @default.
• W1978986554 cites W2012439277 @default.
• W1978986554 cites W2026145805 @default.
• W1978986554 cites W2030547704 @default.
• W1978986554 cites W2031940637 @default.
• W1978986554 cites W2036396440 @default.
• W1978986554 cites W2040049613 @default.
• W1978986554 cites W2044629144 @default.
• W1978986554 cites W2047644811 @default.
• W1978986554 cites W2048642027 @default.
• W1978986554 cites W2052976658 @default.
• W1978986554 cites W2061200435 @default.
• W1978986554 cites W2070037836 @default.
• W1978986554 cites W2076210913 @default.
• W1978986554 cites W2076559561 @default.
• W1978986554 cites W2077999459 @default.
• W1978986554 cites W2085261165 @default.
• W1978986554 cites W2088988321 @default.
• W1978986554 cites W2104465251 @default.
• W1978986554 cites W2113672740 @default.
• W1978986554 cites W2127917887 @default.
• W1978986554 cites W2133187260 @default.
• W1978986554 cites W2151229034 @default.
• W1978986554 cites W2151808726 @default.
• W1978986554 cites W2153526297 @default.
• W1978986554 cites W2164647651 @default.
• W1978986554 cites W2164856821 @default.
• W1978986554 cites W2166818638 @default.
• W1978986554 cites W2167303815 @default.
• W1978986554 cites W2171718050 @default.
• W1978986554 cites W2341772994 @default.
• W1978986554 cites W789458867 @default.
• W1978986554 doi "https://doi.org/10.1016/s0006-3495(96)79584-x" @default.
• W1978986554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1224939" @default.
• W1978986554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8770217" @default.
• W1978986554 hasPublicationYear "1996" @default.
• W1978986554 type Work @default.
• W1978986554 sameAs 1978986554 @default.
• W1978986554 citedByCount "42" @default.
• W1978986554 countsByYear W19789865542012 @default.
• W1978986554 countsByYear W19789865542017 @default.
• W1978986554 countsByYear W19789865542019 @default.
• W1978986554 countsByYear W19789865542022 @default.
• W1978986554 crossrefType "journal-article" @default.
• W1978986554 hasAuthorship W1978986554A5035642806 @default.
• W1978986554 hasBestOaLocation W19789865541 @default.
• W1978986554 hasConcept C103486182 @default.
• W1978986554 hasConcept C105702510 @default.
• W1978986554 hasConcept C12554922 @default.
• W1978986554 hasConcept C125705527 @default.
• W1978986554 hasConcept C126322002 @default.
• W1978986554 hasConcept C133927893 @default.
• W1978986554 hasConcept C14228908 @default.
• W1978986554 hasConcept C174054327 @default.
• W1978986554 hasConcept C178790620 @default.
• W1978986554 hasConcept C185592680 @default.
• W1978986554 hasConcept C2776050358 @default.
• W1978986554 hasConcept C2777132085 @default.
• W1978986554 hasConcept C2779959927 @default.
• W1978986554 hasConcept C36036425 @default.
• W1978986554 hasConcept C500558357 @default.
• W1978986554 hasConcept C519063684 @default.
• W1978986554 hasConcept C55493867 @default.
• W1978986554 hasConcept C71924100 @default.
• W1978986554 hasConcept C86803240 @default.
• W1978986554 hasConceptScore W1978986554C103486182 @default.
• W1978986554 hasConceptScore W1978986554C105702510 @default.
• W1978986554 hasConceptScore W1978986554C12554922 @default.
• W1978986554 hasConceptScore W1978986554C125705527 @default.
• W1978986554 hasConceptScore W1978986554C126322002 @default.
• W1978986554 hasConceptScore W1978986554C133927893 @default.
• W1978986554 hasConceptScore W1978986554C14228908 @default.
• W1978986554 hasConceptScore W1978986554C174054327 @default.
• W1978986554 hasConceptScore W1978986554C178790620 @default.
• W1978986554 hasConceptScore W1978986554C185592680 @default.
• W1978986554 hasConceptScore W1978986554C2776050358 @default.
• W1978986554 hasConceptScore W1978986554C2777132085 @default.
• W1978986554 hasConceptScore W1978986554C2779959927 @default.
• W1978986554 hasConceptScore W1978986554C36036425 @default.
• W1978986554 hasConceptScore W1978986554C500558357 @default.
• W1978986554 hasConceptScore W1978986554C519063684 @default.
• W1978986554 hasConceptScore W1978986554C55493867 @default.

• next