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• W1978991192 endingPage "186" @default.
• W1978991192 startingPage "167" @default.
• W1978991192 abstract "Dopamine (DA) axon terminals (varicosities) in the neostriatum of adult rats were examined for shape, size, content, synaptic incidence, type of junction, synaptic targets, and microenvironment after electron microscopic identification either by [3H]DA uptake autoradiography or by immunocytochemistry with monoclonal antibodies against DA-glutaraldehyde-protein conjugate. Both approaches yielded comparable results. Whether they were from the paraventricular or the mediodorsal neostriatum, respectively, the [3H]DA-labeled and DA-immunostained varicosities were generally oblong and relatively small; more than 60% contained one or more mitochondria. Sixty to seventy percent were asynaptic, and 30-40% were endowed with a synaptic membrane differentiation (junctional complex), as inferred by stereological extrapolation from single thin sections (both approaches) or observed directly in long, uninterrupted series of thin sections (immunocytochemistry). The synaptic DA varicosities always displayed symmetrical junctions: 67% with dendritic branches, 30% with dendritic spines, and 2-3% with neuronal cell bodies. DA varicosities juxtaposed to one another were frequent. Other axonal varicosities were more numerous in the immediate vicinity of DA varicosities than around randomly selected, unlabeled terminals. The respective microenvironments of DA and unlabeled varicosities also showed enrichment in the preferred synaptic targets of both groups of varicosities, with dendritic branches for DA and dendritic spines for the unlabeled ones. These data suggest a dual mode of operation that is diffuse as well as synaptic for the nigrostriatal DA system. In such a densely DA-innervated brain region, they also lead to the hypothesis that a basal level of extracellular DA might be maintained permanently around every tissue constituent and, thus, contribute to the mechanisms of action, properties, and functions (or dysfunctions) of DA within the neostriatum itself and as part of the basal ganglia circuitry." @default.
• W1978991192 created "2016-06-24" @default.
• W1978991192 creator A5043115563 @default.
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• W1978991192 creator A5067161685 @default.
• W1978991192 creator A5084074058 @default.
• W1978991192 creator A5089497758 @default.
• W1978991192 date "1996-11-11" @default.
• W1978991192 modified "2023-10-17" @default.
• W1978991192 title "Dual character, asynaptic and synaptic, of the dopamine innervation in adult rat neostriatum: A quantitative autoradiographic and immunocytochemical analysis" @default.
• W1978991192 cites W1571707534 @default.
• W1978991192 cites W1625996387 @default.
• W1978991192 cites W175006040 @default.
• W1978991192 cites W1897632924 @default.
• W1978991192 cites W1964494222 @default.
• W1978991192 cites W1965714279 @default.
• W1978991192 cites W1967458028 @default.
• W1978991192 cites W1974520523 @default.
• W1978991192 cites W1975291812 @default.
• W1978991192 cites W1978073760 @default.
• W1978991192 cites W1979428849 @default.
• W1978991192 cites W1979465510 @default.
• W1978991192 cites W1980016842 @default.
• W1978991192 cites W1980310343 @default.
• W1978991192 cites W1980318946 @default.
• W1978991192 cites W1981719943 @default.
• W1978991192 cites W1986525261 @default.
• W1978991192 cites W1987965502 @default.
• W1978991192 cites W1990230925 @default.
• W1978991192 cites W1991603311 @default.
• W1978991192 cites W1993858763 @default.
• W1978991192 cites W1993861337 @default.
• W1978991192 cites W1996498301 @default.
• W1978991192 cites W1996916011 @default.
• W1978991192 cites W1997545254 @default.
• W1978991192 cites W1999510004 @default.
• W1978991192 cites W1999709859 @default.
• W1978991192 cites W2001181389 @default.
• W1978991192 cites W2004101827 @default.
• W1978991192 cites W2005235262 @default.
• W1978991192 cites W2005673668 @default.
• W1978991192 cites W2010279907 @default.
• W1978991192 cites W2013061015 @default.
• W1978991192 cites W2013975662 @default.
• W1978991192 cites W2014544605 @default.
• W1978991192 cites W2014988996 @default.
• W1978991192 cites W2017111083 @default.
• W1978991192 cites W2024398768 @default.
• W1978991192 cites W2026381642 @default.
• W1978991192 cites W2028183577 @default.
• W1978991192 cites W2029298105 @default.
• W1978991192 cites W2030131397 @default.
• W1978991192 cites W2031219969 @default.
• W1978991192 cites W2031890124 @default.
• W1978991192 cites W2033904402 @default.
• W1978991192 cites W2034942361 @default.
• W1978991192 cites W2035682750 @default.
• W1978991192 cites W2039732315 @default.
• W1978991192 cites W2039884145 @default.
• W1978991192 cites W2041932757 @default.
• W1978991192 cites W2042329023 @default.
• W1978991192 cites W2044182043 @default.
• W1978991192 cites W2044768013 @default.
• W1978991192 cites W2044972351 @default.
• W1978991192 cites W2047150412 @default.
• W1978991192 cites W2048646915 @default.
• W1978991192 cites W2048654901 @default.
• W1978991192 cites W2051406811 @default.
• W1978991192 cites W2051549473 @default.
• W1978991192 cites W2052699392 @default.
• W1978991192 cites W2053603509 @default.
• W1978991192 cites W2054265484 @default.
• W1978991192 cites W2054719361 @default.
• W1978991192 cites W2058250190 @default.
• W1978991192 cites W2063072517 @default.
• W1978991192 cites W2063746042 @default.
• W1978991192 cites W2064392759 @default.
• W1978991192 cites W2071857109 @default.
• W1978991192 cites W2074852535 @default.
• W1978991192 cites W2075021671 @default.
• W1978991192 cites W2075483684 @default.
• W1978991192 cites W2075893551 @default.
• W1978991192 cites W2075952655 @default.
• W1978991192 cites W2075996950 @default.
• W1978991192 cites W2076041400 @default.
• W1978991192 cites W2076140644 @default.
• W1978991192 cites W2077657160 @default.
• W1978991192 cites W2077802026 @default.
• W1978991192 cites W2078633164 @default.
• W1978991192 cites W2080367548 @default.
• W1978991192 cites W2081629364 @default.
• W1978991192 cites W2082038879 @default.
• W1978991192 cites W2083915232 @default.
• W1978991192 cites W2085291810 @default.
• W1978991192 cites W2085899483 @default.
• W1978991192 cites W2088222083 @default.
• W1978991192 cites W2088495343 @default.
• W1978991192 cites W2090006102 @default.

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