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• W1978991202 abstract "Assembly of a fibronectin (FN) matrix is a multistep process which influences a number of cellular functions including intracellular cytoskeletal organization and signaling responses. We have previously reported on a recombinant FN (recFN), FN delta III1-7, which differs from native FN in its rate of fibril formation. To determine the intracellular consequences of a delay in assembly, we compared the distribution of cytoskeletal proteins during the formation of native and recFN matrices by immunofluorescence at various time points. CHO alpha 5 cell cytoskeleton was reorganized in response to both native and recFN matrix formation. Assembly of native FN induced a rapid reorganization of actin into stress fibers and colocalization of alpha 5 beta 1 integrin, focal adhesion kinase (FAK), vinculin, and paxillin to regions of cell-matrix contact. alpha 5 beta 1 integrins and FAK are also clustered upon binding of FN delta III1-7 to cells but actin reorganization and focal adhesion formation are delayed and appear to be dependent on the formation of FN delta III1-7 fibrils. These results suggest that the structural framework of the matrix plays an important role in the ability of FN to initiate intracellular responses." @default.
• W1978991202 created "2016-06-24" @default.
• W1978991202 creator A5060548313 @default.
• W1978991202 creator A5073696197 @default.
• W1978991202 date "1997-01-01" @default.
• W1978991202 modified "2023-09-23" @default.
• W1978991202 title "Coordinated Regulation of Fibronectin Fibril Assembly and Actin Stress Fiber Formation" @default.
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• W1978991202 doi "https://doi.org/10.3109/15419069709004458" @default.
• W1978991202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9177903" @default.
• W1978991202 hasPublicationYear "1997" @default.
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