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- W1978992015 abstract "Autism spectrum disorder (ASD) is a childhood neurodevelopmental disorder. During fetal and neonatal brain development, the cues for neurodevelopment are regulated in a well orchestrated manner. Generally, neurotransmitters play a major role in the formation of central nervous system (CNS) and peripheral nervous system (PNS). Glutamate, the excitatory neurotransmitter actively participates in various neurodevelopmental processes through complex regulatory events. Excitatory neurotransmitter signaling via glutamate receptors modulates cognitive functions such as memory and learning, which are usually impaired in ASD. Therefore, glutamate and its regulatory molecules are considered as potential targets for these disorders. Pharmacological, biochemical and behavioral studies reveal possible involvement of glutamatergic system in ASD pathology. An abnormal increase in electrical activity resulting from excessive glutamate signaling causes prolonged alterations in behavior, as commonly seen in ASDs. On the contrary, reports on animal models of hypoglutamatergia demonstrate phenotypes that overlap with features seen in autism. So controversies prevail whether to regard autism as hyper- or hypo-glutamatergic disorder. This paper reviews the role of glutamate and its regulatory proteins such as different receptors, transporters and metabolizing enzymes in the pathophysiology of ASD based on evidences gathered through multidisciplinary approaches. All these information raise the possibility of exploiting glutamatergic neurotransmitter system for future therapeutic interventions for ASD." @default.
- W1978992015 created "2016-06-24" @default.
- W1978992015 creator A5002722462 @default.
- W1978992015 creator A5074615722 @default.
- W1978992015 creator A5086994894 @default.
- W1978992015 date "2012-02-01" @default.
- W1978992015 modified "2023-09-26" @default.
- W1978992015 title "Glutamate mediated signaling in the pathophysiology of autism spectrum disorders" @default.
- W1978992015 cites W1488489801 @default.
- W1978992015 cites W1503862109 @default.
- W1978992015 cites W1506956777 @default.
- W1978992015 cites W1555175985 @default.
- W1978992015 cites W1612819372 @default.
- W1978992015 cites W164401598 @default.
- W1978992015 cites W1794950817 @default.
- W1978992015 cites W1922813693 @default.
- W1978992015 cites W1963940970 @default.
- W1978992015 cites W1967357484 @default.
- W1978992015 cites W1968692478 @default.
- W1978992015 cites W1968702905 @default.
- W1978992015 cites W1970096763 @default.
- W1978992015 cites W1975890560 @default.
- W1978992015 cites W1976289522 @default.
- W1978992015 cites W1976366566 @default.
- W1978992015 cites W1977347112 @default.
- W1978992015 cites W1978885851 @default.
- W1978992015 cites W1979191565 @default.
- W1978992015 cites W1979386418 @default.
- W1978992015 cites W1979421307 @default.
- W1978992015 cites W1981114447 @default.
- W1978992015 cites W1983197885 @default.
- W1978992015 cites W1984554847 @default.
- W1978992015 cites W1984766312 @default.
- W1978992015 cites W1985959949 @default.
- W1978992015 cites W1988676936 @default.
- W1978992015 cites W1991701465 @default.
- W1978992015 cites W1992521533 @default.
- W1978992015 cites W1995739615 @default.
- W1978992015 cites W1995806013 @default.
- W1978992015 cites W1997906889 @default.
- W1978992015 cites W1999515216 @default.
- W1978992015 cites W2002195122 @default.
- W1978992015 cites W2002869948 @default.
- W1978992015 cites W2004974601 @default.
- W1978992015 cites W2005325329 @default.
- W1978992015 cites W2006522177 @default.
- W1978992015 cites W2008170442 @default.
- W1978992015 cites W2008189718 @default.
- W1978992015 cites W2009082639 @default.
- W1978992015 cites W2010004476 @default.
- W1978992015 cites W2010307662 @default.
- W1978992015 cites W2016207558 @default.
- W1978992015 cites W2020404701 @default.
- W1978992015 cites W2020944683 @default.
- W1978992015 cites W2024948778 @default.
- W1978992015 cites W2026441290 @default.
- W1978992015 cites W2027671847 @default.
- W1978992015 cites W2029858747 @default.
- W1978992015 cites W2030214963 @default.
- W1978992015 cites W2031544109 @default.
- W1978992015 cites W2031785254 @default.
- W1978992015 cites W2031827634 @default.
- W1978992015 cites W2032360884 @default.
- W1978992015 cites W2032444015 @default.
- W1978992015 cites W2032492847 @default.
- W1978992015 cites W2033937779 @default.
- W1978992015 cites W2034666232 @default.
- W1978992015 cites W2034824489 @default.
- W1978992015 cites W2041224810 @default.
- W1978992015 cites W2042297319 @default.
- W1978992015 cites W2043166209 @default.
- W1978992015 cites W2045192866 @default.
- W1978992015 cites W2045916207 @default.
- W1978992015 cites W2047266773 @default.
- W1978992015 cites W2048220035 @default.
- W1978992015 cites W2048587560 @default.
- W1978992015 cites W2050422293 @default.
- W1978992015 cites W2055182433 @default.
- W1978992015 cites W2057847288 @default.
- W1978992015 cites W2059900297 @default.
- W1978992015 cites W2060925776 @default.
- W1978992015 cites W2065169201 @default.
- W1978992015 cites W2066358338 @default.
- W1978992015 cites W2067795636 @default.
- W1978992015 cites W2068468110 @default.
- W1978992015 cites W2070754102 @default.
- W1978992015 cites W2071090844 @default.
- W1978992015 cites W2073650605 @default.
- W1978992015 cites W2073789713 @default.
- W1978992015 cites W2074683128 @default.
- W1978992015 cites W2080287250 @default.
- W1978992015 cites W2080322742 @default.
- W1978992015 cites W2080699191 @default.
- W1978992015 cites W2081713212 @default.
- W1978992015 cites W2082109123 @default.
- W1978992015 cites W2084889756 @default.
- W1978992015 cites W2088315426 @default.
- W1978992015 cites W2088477098 @default.