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- W1978996010 startingPage "1145" @default.
- W1978996010 abstract "In the setting of soaring popularity, postmarketing studies of calcium channel blockers came to suggest an increase in a variety of major adverse end points. The evidence, however, was largely observational, and large-scale trials capable of addressing the concerns were wanting. Clinical trials now support the safety and efficacy of the long-acting dihydropyridines for patients with both uncomplicated and diabetic hypertension, although conventional therapies and, in the latter case, angiotensin-converting enzyme inhibitors have superior proof of benefit. By contrast, short-acting dihydropyridines should be avoided. In the acute coronary syndromes, beta-blockers remain the treatment of choice; the evidence for nondihydropyridines remains inconclusive. Stable angina calls for beta-blockers as first-line therapy and nondihydropyridines as second-line therapy, whereas in ventricular dysfunction, safety data for nondihydropyridines are lacking. Initial reports of cancer, bleeding, and suicide have been contradicted by subsequent data, making the associations uncertain or unlikely. Remaining questions await completion of ongoing trials to better define the indications for these agents." @default.
- W1978996010 created "2016-06-24" @default.
- W1978996010 creator A5039797196 @default.
- W1978996010 creator A5047049575 @default.
- W1978996010 date "2001-05-14" @default.
- W1978996010 modified "2023-09-24" @default.
- W1978996010 title "Epidemiologic Review of the Calcium Channel Blocker Drugs" @default.
- W1978996010 cites W137439897 @default.
- W1978996010 cites W1487407525 @default.
- W1978996010 cites W1498412137 @default.
- W1978996010 cites W1535826526 @default.
- W1978996010 cites W1538185747 @default.
- W1978996010 cites W1586179871 @default.
- W1978996010 cites W1594676326 @default.
- W1978996010 cites W163446288 @default.
- W1978996010 cites W180946569 @default.
- W1978996010 cites W1966953116 @default.
- W1978996010 cites W1971027475 @default.
- W1978996010 cites W197138820 @default.
- W1978996010 cites W1975884717 @default.
- W1978996010 cites W1976052010 @default.
- W1978996010 cites W1977364478 @default.
- W1978996010 cites W1978244096 @default.
- W1978996010 cites W1978988374 @default.
- W1978996010 cites W1979082324 @default.
- W1978996010 cites W1980089653 @default.
- W1978996010 cites W1982948421 @default.
- W1978996010 cites W1983494586 @default.
- W1978996010 cites W1983852980 @default.
- W1978996010 cites W1985388908 @default.
- W1978996010 cites W1985435023 @default.
- W1978996010 cites W1987856014 @default.
- W1978996010 cites W1990452981 @default.
- W1978996010 cites W1991046646 @default.
- W1978996010 cites W1991977300 @default.
- W1978996010 cites W1992136793 @default.
- W1978996010 cites W1996935712 @default.
- W1978996010 cites W1999904792 @default.
- W1978996010 cites W2000578790 @default.
- W1978996010 cites W2004047790 @default.
- W1978996010 cites W2006377181 @default.
- W1978996010 cites W2006751378 @default.
- W1978996010 cites W2006825115 @default.
- W1978996010 cites W2007607974 @default.
- W1978996010 cites W2012416553 @default.
- W1978996010 cites W2012897198 @default.
- W1978996010 cites W2014750372 @default.
- W1978996010 cites W2014815054 @default.
- W1978996010 cites W2017052113 @default.
- W1978996010 cites W2020729977 @default.
- W1978996010 cites W2021061435 @default.
- W1978996010 cites W2024003019 @default.
- W1978996010 cites W2026368068 @default.
- W1978996010 cites W2027409422 @default.
- W1978996010 cites W2027759368 @default.
- W1978996010 cites W2028253538 @default.
- W1978996010 cites W2028294998 @default.
- W1978996010 cites W2029390260 @default.
- W1978996010 cites W2031232834 @default.
- W1978996010 cites W2031850393 @default.
- W1978996010 cites W2032490803 @default.
- W1978996010 cites W2033935388 @default.
- W1978996010 cites W2038118918 @default.
- W1978996010 cites W2039803453 @default.
- W1978996010 cites W2043076806 @default.
- W1978996010 cites W2043415477 @default.
- W1978996010 cites W2046303635 @default.
- W1978996010 cites W2047895902 @default.
- W1978996010 cites W2052440060 @default.
- W1978996010 cites W2054045500 @default.
- W1978996010 cites W2058645062 @default.
- W1978996010 cites W2059686465 @default.
- W1978996010 cites W2065463734 @default.
- W1978996010 cites W2067015533 @default.
- W1978996010 cites W2068995720 @default.
- W1978996010 cites W2072184670 @default.
- W1978996010 cites W2072968785 @default.
- W1978996010 cites W2073109804 @default.
- W1978996010 cites W2074108261 @default.
- W1978996010 cites W2077120460 @default.
- W1978996010 cites W2079624245 @default.
- W1978996010 cites W2083084535 @default.
- W1978996010 cites W2083625183 @default.
- W1978996010 cites W2083772300 @default.
- W1978996010 cites W2085258016 @default.
- W1978996010 cites W2086374819 @default.
- W1978996010 cites W2088276331 @default.
- W1978996010 cites W2089435924 @default.
- W1978996010 cites W2089964124 @default.
- W1978996010 cites W2090674352 @default.
- W1978996010 cites W2091804164 @default.
- W1978996010 cites W2091978623 @default.
- W1978996010 cites W2092805838 @default.
- W1978996010 cites W2093009820 @default.
- W1978996010 cites W2098887440 @default.
- W1978996010 cites W2099198771 @default.
- W1978996010 cites W2102851109 @default.
- W1978996010 cites W2102979143 @default.