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- W1978996422 abstract "This work describes X-ray imaging of mouse using colloid solution of silica coated Au (Au/SiO2) nanoparticles surface modified with poly(ethylene glycol) (PEG) (Au/SiO2/PEG). A colloid solution of Au nanoparticles was prepared by reducing Au ions (III) with sodium citrate. Au/SiO2 nanoparticles were fabricated by a sol–gel method using tetraethylorthosilicate, water and sodium hydroxide in ethanol in the presence of Au nanoparticles surface modified with (3-aminopropyl)trimethoxysilane. A computed tomography value of the Au/SiO2 colloid solution with an Au concentration of 0·083M was as high as 1421·2 Hounsfield units, which was higher than that of a commercial X-ray contrast agent with the same iodine concentration. Surface modification of the Au/SiO2 particles with PEG, or PEGylation of the particle surface, was performed using (3-aminopropyl)trimethoxysilane and PEG for the Au/SiO2 particles. Tissues of mouse could be imaged by injecting the colloid solutions of Au/SiO2 particles or Au/SiO2/PEG particles into it. The PEGylation provided an increase in residence time of particles in the mouse." @default.
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- W1978996422 date "2013-11-01" @default.
- W1978996422 modified "2023-09-27" @default.
- W1978996422 title "X-ray imaging technique using colloid solution of Au/silica/poly(ethylene glycol) nanoparticles" @default.
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- W1978996422 doi "https://doi.org/10.1179/1433075x13y.0000000100" @default.
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