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- W1979009634 endingPage "57" @default.
- W1979009634 startingPage "46" @default.
- W1979009634 abstract "Major efforts have been directed towards the identification of genetic mutations, their use as biomarkers, and the understanding of their consequences on human health and well-being. There is an emerging interest, however, in the possibility that environmentally-induced changes at levels other than the genetic information could have long-lasting consequences as well. This review summarises our current knowledge of how the environment, nutrition, and ageing affect the way mammalian genes are organised and transcribed, without changes in the underlying DNA sequence. Admittedly, the link between environment and epigenetics remains largely to be explored. However, recent studies indicate that environmental factors and diet can perturb the way genes are controlled by DNA methylation and covalent histone modifications. Unexpectedly, and not unlike genetic mutations, aberrant epigenetic alterations and their phenotypic effects can sometimes be passed on to the next generation." @default.
- W1979009634 created "2016-06-24" @default.
- W1979009634 creator A5072750683 @default.
- W1979009634 date "2006-08-01" @default.
- W1979009634 modified "2023-10-18" @default.
- W1979009634 title "Environmental and nutritional effects on the epigenetic regulation of genes" @default.
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- W1979009634 doi "https://doi.org/10.1016/j.mrfmmm.2006.05.029" @default.
- W1979009634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16854438" @default.
- W1979009634 hasPublicationYear "2006" @default.