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- W1979012392 abstract "The duration and ionic dependence of action potentials change during the differentiation of embryonic amphibian spinal neurons both in vivo and in culture. The development of sodium, calcium, and potassium currents has been characterized in these cells and the shortening of the action potential has been shown to depend to a great extent on developmental changes of potassium currents. Previous evidence suggests that a chloride current may also be present in these embryonic neurons. Chloride currents were investigated with intracellular current-clamp and single-electrode and whole-cell voltage-clamp techniques. Most neurons exhibited a calcium-activated chloride current (ICl(Ca] that contributed to the postdepolarization following the action potential recorded in the absence of sodium and potassium currents. This current appeared to decrease in density and its deactivation rate increased during the first day in culture. Its incidence also declined during this period. A much larger Ca(2+)-dependent Cl- current was also observed in a subset of neurons after 24 hr, but was absent at earlier stages of development. The results suggest the presence of two Cl- currents with different developmental fates. The early current probably contributes to the repolarization of long calcium-dependent action potentials at initial stages of neuronal development, when potassium currents are small, and may serve to reduce the extent of repetitive firing." @default.
- W1979012392 created "2016-06-24" @default.
- W1979012392 creator A5005165225 @default.
- W1979012392 date "1991-09-01" @default.
- W1979012392 modified "2023-09-27" @default.
- W1979012392 title "Developmental change in calcium-activated chloride current during the differentiation of Xenopus spinal neurons in culture" @default.
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- W1979012392 doi "https://doi.org/10.1016/s0012-1606(05)80020-x" @default.
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