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• W1979015046 abstract "Budding yeast Mec1, homolog of mammalian ATR, is an essential protein that mediates S-phase checkpoint responses and meiotic recombination. Elimination of Mec1 function leads to genomewide fork stalling followed by chromosome breakage. Breaks do not result from stochastic collapse of stalled forks or other incidental lesions; instead, they occur in specific regions of the genome during a G 2 chromosomal transition. Break regions are found to be genetically encoded replication slow zones ( RSZ s), a newly discovered yeast chromosomal determinant. Thus, Mec1 has important functions in normal S phase and the genome instability of mec1 (and, analogously, ATR −/− ) mutants stems from defects in these basic roles." @default.
• W1979015046 created "2016-06-24" @default.
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• W1979015046 date "2002-07-26" @default.
• W1979015046 modified "2023-10-18" @default.
• W1979015046 title "ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones" @default.
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• W1979015046 doi "https://doi.org/10.1126/science.1071398" @default.
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