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• W1979022023 abstract "Whether proteins or lipids are the primary target sites for general anesthetic action has engendered considerable debate. Recent in vivo studies have shown that the S(+) and R(-) enantiomers of isoflurane are not equipotent, implying involvement of proteins. Bovine serum albumin (BSA), a soluble protein devoid of lipid, contains specific binding sites for isoflurane and other anesthetics. We therefore conducted 19F nuclear magnetic resonance measurements to determine whether binding of isoflurane to BSA was stereoselective. Isoflurane chemical shifts were measured as a function of BSA concentration to determine the chemical shift differences between the free and bound isoflurane. KD was determined by measuring the 19F transverse relaxation times (T2) as a function of isoflurane concentration. The binding duration was determined by assessing increases in 1/T2 as a result of isoflurane exchanging between the free and bound states. The S(+) and R(-) enantiomers exhibited no stereoselectivity in chemical shifts and KD values (KD = 1.3 +/- 0.2 mM, mean +/- SE, for S(+), R(-), and the racemic mixture). Nonetheless, stereoselectivity was observed in dynamic binding parameters; the S(+) enantiomer bound with slower association and dissociation rates than the R(-)." @default.
• W1979022023 created "2016-06-24" @default.
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• W1979022023 date "1996-01-01" @default.
• W1979022023 modified "2023-10-14" @default.
• W1979022023 title "19F nuclear magnetic resonance investigation of stereoselective binding of isoflurane to bovine serum albumin" @default.
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• W1979022023 doi "https://doi.org/10.1016/s0006-3495(96)79599-1" @default.
• W1979022023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1224952" @default.
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