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- W1979032013 abstract "The in vitro potency of neopterin (NP) as an antioxidant and its in vivo activity to suppress alloxan-induced diabetes were investigated. The reduced form of neopterin, 5,6,7,8-tetrahydroneopterin (NPH-4), showed an extremely high superoxide anion radical scavenging activity in two assay systems, i.e. xanthine/xanthine oxidase- and macrophage/phorbol myrislate acetate (PMA)-reaction systems. NPH-4 also inhibited the oxidation of linoleic acid about as effectively as uric acid. Furthermore, NPH-4 and NP effectively suppressed alloxan-induced mouse diabetes. These results suggest that pteridines play an important role as endogenous antioxidant." @default.
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- W1979032013 date "1992-06-15" @default.
- W1979032013 modified "2023-09-25" @default.
- W1979032013 title "Neopterin as an endogenous antioxidant" @default.
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- W1979032013 doi "https://doi.org/10.1016/0014-5793(92)80610-s" @default.
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