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- W1979033296 abstract "Pentylenetetrazol (PTZ) has been reported to produce a discriminative stimulus related to anxiety and antagonized by the classical anxiolytics. In the present investigation, a variety of compounds with either benzodiazepine (BZ)-type anxiolytic actions or other novel mechanisms of action (serotonin and N-methyl-D-aspartate [NMDA] antagonism) were tested for their ability to antagonize this stimulus. Compounds that have been shown to modulate benzodiazepine receptor function were active in blocking PTZ, the discriminative stimulus. The failure of the other compounds to block these stimuli suggests that the PTZ discrimination may be selective for substances that modulate, either directly or indirectly, the BZ receptor complex." @default.
- W1979033296 created "2016-06-24" @default.
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- W1979033296 date "1989-01-01" @default.
- W1979033296 modified "2023-09-24" @default.
- W1979033296 title "Pentylenetetrazol discriminative stimuli are selective for identifying benzodiazepine receptor modulating agents" @default.
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- W1979033296 doi "https://doi.org/10.1002/ddr.430170307" @default.
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