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- W1979041721 abstract "Autism, a neurodevelopmental disorder, is characterized by abnormal social interactions, impaired social communication and repetitive behaviors and/or restricted interests, along with several associated symptoms including irritability and anxiety. Risperidone is approved for the irritability and self-injurious behaviors found in autism. Fluoxetine is under evaluation for the repetitive behaviors and anxiety associated with autism. These two drugs were evaluated in the BTBR T + tf/J (BTBR) mouse model of autism and C57BL/6J (B6) mice by using the three-chambered social approach test and elevated plus maze to determine effects on sociability and anxiety. Fluoxetine increased sociability, defined as time spent with a stranger mouse, in the BTBR mice without affecting anxiety-like behavior in the elevated plus maze. Fluoxetine did not significantly change either behavior in the B6 mice. Risperidone did not affect sociability or anxiety-like behaviors and had a sedative-like effect at higher doses. These findings suggest that fluoxetine may have some therapeutic efficacy for treating the social behaviors in autism." @default.
- W1979041721 created "2016-06-24" @default.
- W1979041721 creator A5008131329 @default.
- W1979041721 date "2011-01-01" @default.
- W1979041721 modified "2023-09-24" @default.
- W1979041721 title "Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism" @default.
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- W1979041721 doi "https://doi.org/10.1016/j.pbb.2010.09.012" @default.
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