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• W1979044361 abstract "Former studies in rats demonstrated that starvation or treatment with the hypolipidemic drug clofibrate causes a marked increase in the concentration of carnitine in the liver. The molecular mechanisms underlying these phenomena in rats, however, have been largely unknown. Since both, fasting and clofibrate treatment lead to an activation of peroxisome proliferator-activated receptor α (PPARα), the hypothesis has been raised that activation of this nuclear receptor could lead to an up-regulation of novel organic cation transporters (OCTN) which facilitate transport of carnitine and several other organic cations through membranes. Studies in rodents and pigs have indeed shown that treatment with PPARα agonists causes an up-regulation of OCTN2 in liver and other tissues such as muscle and small intestine. Additional experiments with PPARα-null and corresponding wild-type mice, which were either fasted or treated with the high-affinity PPARα agonist WY-14,643, revealed that transcriptional up-regulation of OCTN2 and OCTN3 is dependent on PPARα. An up-regulation of OCTN by PPARα activation could be regarded as a means to supply cells with sufficient carnitine required for transport of excessive amounts of fatty acids into the mitochondrion during fasting, and therefore plays an important role in the adaptive response of the metabolism to fasting. Due to the strong similarities in the gene response to PPARα agonists and the similar metabolic features and anatomic conditions between pigs and humans, it is likely that pharmacological PPARα agonists exert similar effects in humans." @default.
• W1979044361 created "2016-06-24" @default.
• W1979044361 creator A5030594645 @default.
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• W1979044361 date "2010-02-01" @default.
• W1979044361 modified "2023-10-09" @default.
• W1979044361 title "The role of peroxisome proliferator-activated receptor α in transcriptional regulation of novel organic cation transporters" @default.
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• W1979044361 doi "https://doi.org/10.1016/j.ejphar.2009.11.042" @default.
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