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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979047029> ?p ?o ?g. }

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• W1979047029 startingPage "1069" @default.
• W1979047029 abstract "Intracerebroventricular (ICV) injection of Agouti related protein (AgRP), an endogenous melanocortin 3 and 4 receptor (MC3/4-R) antagonist, produces a prolonged increase in food intake. To clarify the roles of the MC3-R and MC4-R in AgRP-induced hyperphagia, the feeding effect of AgRP (83-132) was compared with that of the selective MC4-R antagonist, JKC-363 (cyclic [Mpr11, D-Nal14, Cys18, Asp22-NH2]-beta-MSH11-22). Single ICV administration of AgRP (83-132) increased food intake for 48 h whilst ICV JKC-363 increased food intake for 8h. An increase in body weight at 24 and 48 h was observed following AgRP (83-132) but not JKC-363 treatment. These data suggest that the sustained orexigenic action of AgRP (83-132) may not be through MC4-R antagonism." @default.
• W1979047029 created "2016-06-24" @default.
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• W1979047029 date "2002-06-01" @default.
• W1979047029 modified "2023-10-12" @default.
• W1979047029 title "Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor" @default.
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• W1979047029 doi "https://doi.org/10.1016/s0196-9781(02)00039-6" @default.
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