FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979061530> ?p ?o ?g. }

• W1979061530 endingPage "442" @default.
• W1979061530 startingPage "434" @default.
• W1979061530 abstract "Biomonitoring data are now available for hundreds of chemicals through state and national health surveys. Exposure guidance values also exist for many of these chemicals. Several methods are frequently used to evaluate biomarker data with respect to a guidance value. The “biomonitoring equivalent” (BE) approach estimates a single biomarker concentration (called the BE) that corresponds to a guidance value (e.g., Maximum Contaminant Level, Reference Dose, etc.), which can then be compared with measured biomarker data. The resulting “hazard quotient” estimates (HQ = biomarker concentration/BE) can then be used to prioritize chemicals for follow-up examinations. This approach is used exclusively for population-level assessments, and works best when the central tendency of measurement data is considered. Complementary approaches are therefore needed for assessing individual biomarker levels, particularly those that fall within the upper percentiles of measurement distributions. In this case study, probabilistic models were first used to generate distributions of BEs for perchlorate based on the point-of-departure (POD) of 7 μg/kg/day. These distributions reflect possible biomarker concentrations in a hypothetical population where all individuals are exposed at the POD. A statistical analysis was then performed to evaluate urinary perchlorate measurements from adults in the 2001 to 2002 National Health and Nutrition Examination Survey (NHANES). Each NHANES adult was assumed to have experienced repeated exposure at the POD, and their biomarker concentration was interpreted probabilistically with respect to a BE distribution. The HQ based on the geometric mean (GM) urinary perchlorate concentration was estimated to be much lower than unity (HQ ≈ 0.07). This result suggests that the average NHANES adult was exposed to perchlorate at a level well below the POD. Regarding individuals, at least a 99.8% probability was calculated for all but two NHANES adults that a higher biomarker concentration would have been observed compared to what was actually measured if the daily dietary exposure had been at the POD. This is strong evidence that individual perchlorate exposures in the 2001–2002 NHANES adult population were likely well below the POD. This case study demonstrates that the “stochastic BE approach” provides useful quantitative metrics, in addition to HQ estimates, for comparison across chemicals. This methodology should be considered when evaluating biomarker measurements against exposure guidance values, and when examining chemicals that have been identified as needing follow-up investigation based on existing HQ estimates." @default.
• W1979061530 created "2016-06-24" @default.
• W1979061530 creator A5027712785 @default.
• W1979061530 creator A5029174596 @default.
• W1979061530 creator A5037229950 @default.
• W1979061530 creator A5048566926 @default.
• W1979061530 creator A5061461803 @default.
• W1979061530 creator A5066072097 @default.
• W1979061530 date "2014-08-01" @default.
• W1979061530 modified "2023-10-06" @default.
• W1979061530 title "A new method for generating distributions of biomonitoring equivalents to support exposure assessment and prioritization" @default.
• W1979061530 cites W1975278258 @default.
• W1979061530 cites W1991497351 @default.
• W1979061530 cites W1993433812 @default.
• W1979061530 cites W2008317278 @default.
• W1979061530 cites W2012133139 @default.
• W1979061530 cites W2024675985 @default.
• W1979061530 cites W2027235935 @default.
• W1979061530 cites W2030465465 @default.
• W1979061530 cites W2035150223 @default.
• W1979061530 cites W2036890940 @default.
• W1979061530 cites W2052962549 @default.
• W1979061530 cites W2068552207 @default.
• W1979061530 cites W2074259961 @default.
• W1979061530 cites W2079199943 @default.
• W1979061530 cites W2081702786 @default.
• W1979061530 cites W2086286700 @default.
• W1979061530 cites W2093988452 @default.
• W1979061530 cites W2100901504 @default.
• W1979061530 cites W2110069566 @default.
• W1979061530 cites W2122309597 @default.
• W1979061530 cites W2130205238 @default.
• W1979061530 cites W2140558148 @default.
• W1979061530 cites W2147334256 @default.
• W1979061530 doi "https://doi.org/10.1016/j.yrtph.2014.05.008" @default.
• W1979061530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24845241" @default.
• W1979061530 hasPublicationYear "2014" @default.
• W1979061530 type Work @default.
• W1979061530 sameAs 1979061530 @default.
• W1979061530 citedByCount "9" @default.
• W1979061530 countsByYear W19790615302014 @default.
• W1979061530 countsByYear W19790615302015 @default.
• W1979061530 countsByYear W19790615302017 @default.
• W1979061530 countsByYear W19790615302018 @default.
• W1979061530 countsByYear W19790615302020 @default.
• W1979061530 countsByYear W19790615302021 @default.
• W1979061530 crossrefType "journal-article" @default.
• W1979061530 hasAuthorship W1979061530A5027712785 @default.
• W1979061530 hasAuthorship W1979061530A5029174596 @default.
• W1979061530 hasAuthorship W1979061530A5037229950 @default.
• W1979061530 hasAuthorship W1979061530A5048566926 @default.
• W1979061530 hasAuthorship W1979061530A5061461803 @default.
• W1979061530 hasAuthorship W1979061530A5066072097 @default.
• W1979061530 hasConcept C105795698 @default.
• W1979061530 hasConcept C107872376 @default.
• W1979061530 hasConcept C109051061 @default.
• W1979061530 hasConcept C122048520 @default.
• W1979061530 hasConcept C185592680 @default.
• W1979061530 hasConcept C198408306 @default.
• W1979061530 hasConcept C2779874844 @default.
• W1979061530 hasConcept C2781197716 @default.
• W1979061530 hasConcept C2908647359 @default.
• W1979061530 hasConcept C33923547 @default.
• W1979061530 hasConcept C39432304 @default.
• W1979061530 hasConcept C55493867 @default.
• W1979061530 hasConcept C71924100 @default.
• W1979061530 hasConcept C99454951 @default.
• W1979061530 hasConceptScore W1979061530C105795698 @default.
• W1979061530 hasConceptScore W1979061530C107872376 @default.
• W1979061530 hasConceptScore W1979061530C109051061 @default.
• W1979061530 hasConceptScore W1979061530C122048520 @default.
• W1979061530 hasConceptScore W1979061530C185592680 @default.
• W1979061530 hasConceptScore W1979061530C198408306 @default.
• W1979061530 hasConceptScore W1979061530C2779874844 @default.
• W1979061530 hasConceptScore W1979061530C2781197716 @default.
• W1979061530 hasConceptScore W1979061530C2908647359 @default.
• W1979061530 hasConceptScore W1979061530C33923547 @default.
• W1979061530 hasConceptScore W1979061530C39432304 @default.
• W1979061530 hasConceptScore W1979061530C55493867 @default.
• W1979061530 hasConceptScore W1979061530C71924100 @default.
• W1979061530 hasConceptScore W1979061530C99454951 @default.
• W1979061530 hasIssue "3" @default.
• W1979061530 hasLocation W19790615301 @default.
• W1979061530 hasLocation W19790615302 @default.
• W1979061530 hasOpenAccess W1979061530 @default.
• W1979061530 hasPrimaryLocation W19790615301 @default.
• W1979061530 hasRelatedWork W1906069082 @default.
• W1979061530 hasRelatedWork W1979061530 @default.
• W1979061530 hasRelatedWork W2006958457 @default.
• W1979061530 hasRelatedWork W2057034767 @default.
• W1979061530 hasRelatedWork W2061068828 @default.
• W1979061530 hasRelatedWork W2558564459 @default.
• W1979061530 hasRelatedWork W2921313054 @default.
• W1979061530 hasRelatedWork W3170956314 @default.
• W1979061530 hasRelatedWork W4320065764 @default.
• W1979061530 hasRelatedWork W2191544798 @default.
• W1979061530 hasVolume "69" @default.
• W1979061530 isParatext "false" @default.

• next