FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979062016> ?p ?o ?g. }

• W1979062016 endingPage "457" @default.
• W1979062016 startingPage "447" @default.
• W1979062016 abstract "Transcriptional silencing by CpG island hypermethylation plays a critical role in endometrial carcinogenesis. In a collection of benign, premalignant and malignant endometrial lesions, a methylation profile of a complete gene panel, such steroid receptors (ERα, PR), DNA mismatch repair (hMLH1), tumor-suppressor genes (CDKN2A/P16 and CDH1/E-CADHERIN) and WNT pathway inhibitors (SFRP1, SFRP2, SFRP4, SFRP5) was investigated in order to demonstrate their pathogenetic role in endometrial lesions. Our results indicate that gene hypermethylation may be an early event in endometrial endometrioid tumorigenesis. Particularly, ERα, PR, hMLH1, CDKN2A/P16, SFRP1, SFRP2 and SFRP5 revealed a promoter methylation status in endometrioid carcinoma, whereas SFRP4 showed demethylation in cancer. P53 immunostaining showed weak-focal protein expression level both in hyperplasic lesions and in endometrioid cancer. Non-endometrioid cancers showed very low levels of epigenetic methylations, but strong P53 protein positivity. Fisher exact test revealed a statistically significant association between hMLH1, CDKN2A/P16 and SFRP1 genes methylation and endometrioid carcinomas and between hMLH1 gene methylation and peritumoral endometrium (p < 0.05). Our data confirm that the methylation profile of the peritumoral endometrium is different from the altered molecular background of benign endometrial polyps and hyperplasias. Therefore, our findings suggest that the methylation of hMLH1, CDKN2A/P16 and SFRP1 may clearly distinguish between benign and malignant lesions. Finally, this study assessed that the use of an epigenetic fingerprint may improve the current diagnostic tools for a better clinical management of endometrial lesions." @default.
• W1979062016 created "2016-06-24" @default.
• W1979062016 creator A5007278785 @default.
• W1979062016 creator A5011678178 @default.
• W1979062016 creator A5021797078 @default.
• W1979062016 creator A5027449385 @default.
• W1979062016 creator A5030269557 @default.
• W1979062016 creator A5030530522 @default.
• W1979062016 creator A5040975801 @default.
• W1979062016 creator A5046311260 @default.
• W1979062016 creator A5050101987 @default.
• W1979062016 creator A5050645858 @default.
• W1979062016 creator A5062732308 @default.
• W1979062016 creator A5066529878 @default.
• W1979062016 creator A5073891277 @default.
• W1979062016 creator A5074761385 @default.
• W1979062016 creator A5077375093 @default.
• W1979062016 creator A5078424935 @default.
• W1979062016 creator A5086343223 @default.
• W1979062016 creator A5087255163 @default.
• W1979062016 creator A5087970528 @default.
• W1979062016 date "2011-09-01" @default.
• W1979062016 modified "2023-10-16" @default.
• W1979062016 title "Epigenetic fingerprint in endometrial carcinogenesis: The hypothesis of a uterine field cancerization" @default.
• W1979062016 cites W1504303645 @default.
• W1979062016 cites W1549730489 @default.
• W1979062016 cites W1579447084 @default.
• W1979062016 cites W1580458764 @default.
• W1979062016 cites W1584238095 @default.
• W1979062016 cites W1627871665 @default.
• W1979062016 cites W1668128989 @default.
• W1979062016 cites W1778855518 @default.
• W1979062016 cites W1787540030 @default.
• W1979062016 cites W1963592300 @default.
• W1979062016 cites W1965769128 @default.
• W1979062016 cites W1975224807 @default.
• W1979062016 cites W1977073465 @default.
• W1979062016 cites W1979652171 @default.
• W1979062016 cites W1989342631 @default.
• W1979062016 cites W1994110056 @default.
• W1979062016 cites W1994465394 @default.
• W1979062016 cites W1995819860 @default.
• W1979062016 cites W1999617682 @default.
• W1979062016 cites W2002378834 @default.
• W1979062016 cites W2002835770 @default.
• W1979062016 cites W2005131800 @default.
• W1979062016 cites W2009983545 @default.
• W1979062016 cites W2010189295 @default.
• W1979062016 cites W2010287588 @default.
• W1979062016 cites W2034066784 @default.
• W1979062016 cites W2040257851 @default.
• W1979062016 cites W2051491915 @default.
• W1979062016 cites W2058842550 @default.
• W1979062016 cites W2065122790 @default.
• W1979062016 cites W2073152187 @default.
• W1979062016 cites W2082514251 @default.
• W1979062016 cites W2085554251 @default.
• W1979062016 cites W2086027966 @default.
• W1979062016 cites W2086470534 @default.
• W1979062016 cites W2088647854 @default.
• W1979062016 cites W2088987931 @default.
• W1979062016 cites W2090754786 @default.
• W1979062016 cites W2091611649 @default.
• W1979062016 cites W2092169530 @default.
• W1979062016 cites W2092688423 @default.
• W1979062016 cites W2093738182 @default.
• W1979062016 cites W2097113048 @default.
• W1979062016 cites W2105174815 @default.
• W1979062016 cites W2106341289 @default.
• W1979062016 cites W2110439369 @default.
• W1979062016 cites W2112134682 @default.
• W1979062016 cites W2118925298 @default.
• W1979062016 cites W2121456510 @default.
• W1979062016 cites W2127724854 @default.
• W1979062016 cites W2132327532 @default.
• W1979062016 cites W2138859400 @default.
• W1979062016 cites W2139015332 @default.
• W1979062016 cites W2140464373 @default.
• W1979062016 cites W2141607880 @default.
• W1979062016 cites W2141662760 @default.
• W1979062016 cites W2144621258 @default.
• W1979062016 cites W2144936572 @default.
• W1979062016 cites W2145034430 @default.
• W1979062016 cites W2155264304 @default.
• W1979062016 cites W2247192901 @default.
• W1979062016 cites W243529564 @default.
• W1979062016 cites W62143101 @default.
• W1979062016 cites W87777578 @default.
• W1979062016 doi "https://doi.org/10.4161/cbt.12.5.15963" @default.
• W1979062016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21709441" @default.
• W1979062016 hasPublicationYear "2011" @default.
• W1979062016 type Work @default.
• W1979062016 sameAs 1979062016 @default.
• W1979062016 citedByCount "38" @default.
• W1979062016 countsByYear W19790620162012 @default.
• W1979062016 countsByYear W19790620162013 @default.
• W1979062016 countsByYear W19790620162014 @default.
• W1979062016 countsByYear W19790620162015 @default.

• next