Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979062455> ?p ?o ?g. }
- W1979062455 endingPage "1130" @default.
- W1979062455 startingPage "1120" @default.
- W1979062455 abstract "Rofecoxib is a highly selective and potent inhibitor of cyclooxgenase-2 (COX-2). Methotrexate is a disease-modifying agent with a narrow therapeutic index frequently prescribed for the management of rheumatoid arthritis. The objective of this study was to investigate the influence of clinical doses of rofecoxib on the pharmacokinetics of methotrexate in patients with rheumatoid arthritis. This was a randomized, double-blind, placebo-controlled study in 25 rheumatoid arthritis patients on stable doses of methotrexate. Patients received oral methotrexate (7.5 to 20 mg) on days-1, 7,14, and 21. Nineteen patients received rofecoxib 12.5, 25, and 50 mg once daily on days 1 to 7, 8 to 14, and 15 to 21, respectively. Six patients received placebo on days1 to 21 only to maintain a double-blinded design for assessment of adverse experiences. Plasma and urine samples were analyzed for methotrexate and its major although inactive metabolite, 7-hydroxymethotrexate. The AUC00–∞ geometric mean ratios (GMR) and their 90% confidence intervals (90% CI) (rofecoxib + methotrexate/methotrexate alone) for day 7/day −1, day 14/day-1, and day 21/day −1, for rofecoxib 12.5, 25, and 50 mg, were 1.03 (0.93, 1.14), 1.02 (0.92, 1.12), and 1.06 (0.96, 1.17), respectively (p > 0.2 for all comparisons to day −1). All AUC0–∞ GMR and Cmax GMR 90% CIs fell within the predefined comparability limits of (0.80, 1.25). Similar results were observed for renal clearance of methotrexate and 7-hydroxymethotrexate at the highest dose of rofecoxib tested (50 mg). It was concluded that rofecoxib at doses of 12.5, 25, and 50 mg once daily has no effect on the plasma concentrations or renal clearance (tested at the highest dose of rofecoxib) of methotrexate in rheumatoid arthritis patients." @default.
- W1979062455 created "2016-06-24" @default.
- W1979062455 creator A5028370411 @default.
- W1979062455 creator A5029778884 @default.
- W1979062455 creator A5034922033 @default.
- W1979062455 creator A5037362834 @default.
- W1979062455 creator A5039276088 @default.
- W1979062455 creator A5046169000 @default.
- W1979062455 creator A5061475254 @default.
- W1979062455 creator A5062360993 @default.
- W1979062455 creator A5068447666 @default.
- W1979062455 creator A5081672652 @default.
- W1979062455 creator A5089683398 @default.
- W1979062455 date "2001-10-01" @default.
- W1979062455 modified "2023-09-26" @default.
- W1979062455 title "Lack of Pharmacokinetic Interaction between Rofecoxib and Methotrexate in Rheumatoid Arthritis Patients" @default.
- W1979062455 cites W1536681507 @default.
- W1979062455 cites W1550111394 @default.
- W1979062455 cites W1966641649 @default.
- W1979062455 cites W1976060163 @default.
- W1979062455 cites W1991520502 @default.
- W1979062455 cites W1995000196 @default.
- W1979062455 cites W1998213501 @default.
- W1979062455 cites W2000421388 @default.
- W1979062455 cites W2001477230 @default.
- W1979062455 cites W2020563114 @default.
- W1979062455 cites W2027453168 @default.
- W1979062455 cites W2028015236 @default.
- W1979062455 cites W2033596995 @default.
- W1979062455 cites W2041252615 @default.
- W1979062455 cites W2042243059 @default.
- W1979062455 cites W2042274378 @default.
- W1979062455 cites W2044750065 @default.
- W1979062455 cites W2050364026 @default.
- W1979062455 cites W2083549800 @default.
- W1979062455 cites W2091566696 @default.
- W1979062455 cites W2099995466 @default.
- W1979062455 cites W2101492631 @default.
- W1979062455 cites W2112187168 @default.
- W1979062455 cites W2118270386 @default.
- W1979062455 cites W2146625461 @default.
- W1979062455 cites W2152851051 @default.
- W1979062455 cites W2158392523 @default.
- W1979062455 cites W2406692965 @default.
- W1979062455 cites W355643970 @default.
- W1979062455 cites W4299800279 @default.
- W1979062455 cites W4321429231 @default.
- W1979062455 doi "https://doi.org/10.1177/00912700122012616" @default.
- W1979062455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11583481" @default.
- W1979062455 hasPublicationYear "2001" @default.
- W1979062455 type Work @default.
- W1979062455 sameAs 1979062455 @default.
- W1979062455 citedByCount "30" @default.
- W1979062455 countsByYear W19790624552012 @default.
- W1979062455 countsByYear W19790624552014 @default.
- W1979062455 countsByYear W19790624552016 @default.
- W1979062455 countsByYear W19790624552017 @default.
- W1979062455 countsByYear W19790624552023 @default.
- W1979062455 crossrefType "journal-article" @default.
- W1979062455 hasAuthorship W1979062455A5028370411 @default.
- W1979062455 hasAuthorship W1979062455A5029778884 @default.
- W1979062455 hasAuthorship W1979062455A5034922033 @default.
- W1979062455 hasAuthorship W1979062455A5037362834 @default.
- W1979062455 hasAuthorship W1979062455A5039276088 @default.
- W1979062455 hasAuthorship W1979062455A5046169000 @default.
- W1979062455 hasAuthorship W1979062455A5061475254 @default.
- W1979062455 hasAuthorship W1979062455A5062360993 @default.
- W1979062455 hasAuthorship W1979062455A5068447666 @default.
- W1979062455 hasAuthorship W1979062455A5081672652 @default.
- W1979062455 hasAuthorship W1979062455A5089683398 @default.
- W1979062455 hasConcept C112705442 @default.
- W1979062455 hasConcept C126322002 @default.
- W1979062455 hasConcept C142724271 @default.
- W1979062455 hasConcept C181199279 @default.
- W1979062455 hasConcept C185592680 @default.
- W1979062455 hasConcept C197934379 @default.
- W1979062455 hasConcept C204787440 @default.
- W1979062455 hasConcept C22979827 @default.
- W1979062455 hasConcept C27081682 @default.
- W1979062455 hasConcept C2777077863 @default.
- W1979062455 hasConcept C2777575956 @default.
- W1979062455 hasConcept C2778582115 @default.
- W1979062455 hasConcept C2779689624 @default.
- W1979062455 hasConcept C2781059491 @default.
- W1979062455 hasConcept C55493867 @default.
- W1979062455 hasConcept C71924100 @default.
- W1979062455 hasConcept C90924648 @default.
- W1979062455 hasConcept C98274493 @default.
- W1979062455 hasConceptScore W1979062455C112705442 @default.
- W1979062455 hasConceptScore W1979062455C126322002 @default.
- W1979062455 hasConceptScore W1979062455C142724271 @default.
- W1979062455 hasConceptScore W1979062455C181199279 @default.
- W1979062455 hasConceptScore W1979062455C185592680 @default.
- W1979062455 hasConceptScore W1979062455C197934379 @default.
- W1979062455 hasConceptScore W1979062455C204787440 @default.
- W1979062455 hasConceptScore W1979062455C22979827 @default.
- W1979062455 hasConceptScore W1979062455C27081682 @default.
- W1979062455 hasConceptScore W1979062455C2777077863 @default.