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- W1979069664 abstract "Significance Stem cells make lineage-choice decisions based on a combination of internal and external signals, including mechanical cues from the surrounding environment. Here we show that Piezo1, an ion channel opened by membrane tension, plays an important role in transducing matrix mechanical information to intracellular pathways affecting differentiation in neural stem cells. Piezo1 activity influences whether neural stem cells differentiate along a neuronal or astrocytic lineage. One of the barriers to successful neural stem cell transplantation therapy for neurological disorders lies in directing the fate of transplanted cells. Pharmacological agents aimed at modulating Piezo1 activity may be useful in directing the fate of transplanted neural stem cells toward the desired lineage." @default.
- W1979069664 created "2016-06-24" @default.
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- W1979069664 date "2014-10-27" @default.
- W1979069664 modified "2023-10-11" @default.
- W1979069664 title "Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells" @default.
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- W1979069664 doi "https://doi.org/10.1073/pnas.1409802111" @default.
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