FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979074507> ?p ?o ?g. }

• W1979074507 endingPage "215" @default.
• W1979074507 startingPage "209" @default.
• W1979074507 abstract "The genetic factors determining the progression of prodromal syndromes to first episode schizophrenia have remained enigmatic to date. In a unique prospective multicentre trial, we assessed whether variants at the D-amino acid oxidase activator (DAOA)/G72 locus influence progression to psychosis. Young subjects with a prodromal syndrome were observed prospectively for up to 2 years to assess the incidence of progression to schizophrenia or first episode psychosis. Of the 82 probands with a prodromal syndrome, 21 probands experienced progression to psychosis within the observation period. Assessment of nine common variants in the DAOA/G72 locus yielded two variants with the predictive value for symptom progression: all four probands with the rs1341402 CC genotype developed psychosis compared with 17 out of 78 probands with the TT or CT genotypes (chi(2) = 12.348; df = 2; p = 0.002). The relative risk for progression to psychosis was significantly increased in the CC genotype: RR = 4.588 (95% CI = 2.175-4.588). Similarly, for rs778294, 50% of probands with the AA genotype, but only 22% of probands with a GG or GA genotype progressed to psychosis (chi(2) = 7.027; df = 2; p = 0.030). Moreover, haplotype analysis revealed a susceptibility haplotype for progression to psychosis. This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia." @default.
• W1979074507 created "2016-06-24" @default.
• W1979074507 creator A5002321122 @default.
• W1979074507 creator A5004754581 @default.
• W1979074507 creator A5009419614 @default.
• W1979074507 creator A5016176374 @default.
• W1979074507 creator A5028897750 @default.
• W1979074507 creator A5037896124 @default.
• W1979074507 creator A5045721609 @default.
• W1979074507 creator A5050012608 @default.
• W1979074507 creator A5054861340 @default.
• W1979074507 creator A5065075154 @default.
• W1979074507 creator A5069577796 @default.
• W1979074507 creator A5071295954 @default.
• W1979074507 creator A5082009517 @default.
• W1979074507 creator A5089666136 @default.
• W1979074507 creator A5091088506 @default.
• W1979074507 date "2009-09-10" @default.
• W1979074507 modified "2023-10-16" @default.
• W1979074507 title "DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis" @default.
• W1979074507 cites W1982395169 @default.
• W1979074507 cites W1996477167 @default.
• W1979074507 cites W2002217801 @default.
• W1979074507 cites W2030705868 @default.
• W1979074507 cites W2034995368 @default.
• W1979074507 cites W2053593733 @default.
• W1979074507 cites W2067318026 @default.
• W1979074507 cites W2067502931 @default.
• W1979074507 cites W2079220045 @default.
• W1979074507 cites W2088772672 @default.
• W1979074507 cites W2090409162 @default.
• W1979074507 cites W2092245401 @default.
• W1979074507 cites W2107755054 @default.
• W1979074507 cites W2127679160 @default.
• W1979074507 cites W2131418825 @default.
• W1979074507 cites W2140606211 @default.
• W1979074507 cites W2148888112 @default.
• W1979074507 cites W2149285245 @default.
• W1979074507 cites W2169889913 @default.
• W1979074507 cites W2171686853 @default.
• W1979074507 cites W4293226656 @default.
• W1979074507 doi "https://doi.org/10.1007/s00406-009-0044-y" @default.
• W1979074507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3128744" @default.
• W1979074507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19763662" @default.
• W1979074507 hasPublicationYear "2009" @default.
• W1979074507 type Work @default.
• W1979074507 sameAs 1979074507 @default.
• W1979074507 citedByCount "32" @default.
• W1979074507 countsByYear W19790745072012 @default.
• W1979074507 countsByYear W19790745072013 @default.
• W1979074507 countsByYear W19790745072014 @default.
• W1979074507 countsByYear W19790745072015 @default.
• W1979074507 countsByYear W19790745072016 @default.
• W1979074507 countsByYear W19790745072017 @default.
• W1979074507 countsByYear W19790745072018 @default.
• W1979074507 countsByYear W19790745072019 @default.
• W1979074507 countsByYear W19790745072020 @default.
• W1979074507 crossrefType "journal-article" @default.
• W1979074507 hasAuthorship W1979074507A5002321122 @default.
• W1979074507 hasAuthorship W1979074507A5004754581 @default.
• W1979074507 hasAuthorship W1979074507A5009419614 @default.
• W1979074507 hasAuthorship W1979074507A5016176374 @default.
• W1979074507 hasAuthorship W1979074507A5028897750 @default.
• W1979074507 hasAuthorship W1979074507A5037896124 @default.
• W1979074507 hasAuthorship W1979074507A5045721609 @default.
• W1979074507 hasAuthorship W1979074507A5050012608 @default.
• W1979074507 hasAuthorship W1979074507A5054861340 @default.
• W1979074507 hasAuthorship W1979074507A5065075154 @default.
• W1979074507 hasAuthorship W1979074507A5069577796 @default.
• W1979074507 hasAuthorship W1979074507A5071295954 @default.
• W1979074507 hasAuthorship W1979074507A5082009517 @default.
• W1979074507 hasAuthorship W1979074507A5089666136 @default.
• W1979074507 hasAuthorship W1979074507A5091088506 @default.
• W1979074507 hasBestOaLocation W19790745071 @default.
• W1979074507 hasConcept C104317684 @default.
• W1979074507 hasConcept C118552586 @default.
• W1979074507 hasConcept C126322002 @default.
• W1979074507 hasConcept C135763542 @default.
• W1979074507 hasConcept C15744967 @default.
• W1979074507 hasConcept C188997412 @default.
• W1979074507 hasConcept C197754878 @default.
• W1979074507 hasConcept C2779727114 @default.
• W1979074507 hasConcept C501734568 @default.
• W1979074507 hasConcept C54355233 @default.
• W1979074507 hasConcept C71924100 @default.
• W1979074507 hasConcept C86803240 @default.
• W1979074507 hasConceptScore W1979074507C104317684 @default.
• W1979074507 hasConceptScore W1979074507C118552586 @default.
• W1979074507 hasConceptScore W1979074507C126322002 @default.
• W1979074507 hasConceptScore W1979074507C135763542 @default.
• W1979074507 hasConceptScore W1979074507C15744967 @default.
• W1979074507 hasConceptScore W1979074507C188997412 @default.
• W1979074507 hasConceptScore W1979074507C197754878 @default.
• W1979074507 hasConceptScore W1979074507C2779727114 @default.
• W1979074507 hasConceptScore W1979074507C501734568 @default.
• W1979074507 hasConceptScore W1979074507C54355233 @default.
• W1979074507 hasConceptScore W1979074507C71924100 @default.
• W1979074507 hasConceptScore W1979074507C86803240 @default.

• next