Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979078001> ?p ?o ?g. }
- W1979078001 endingPage "212" @default.
- W1979078001 startingPage "205" @default.
- W1979078001 abstract "Lignans and flavonoids are naturally-occurring diphenolic compounds found in high concentrations in whole grains, legumes, fruits and vegetables. Seven lignans and six flavonoids were evaluated for their abilities to inhibit aromatase enzyme activity in a human preadipose cell culture system. The lignan, enterolactone (Enl) and its theoretical precursors, 3'-demethoxy-3O-demethylmatairesinol (DMDM) and didemethoxymatairesinol (DDMM) decreased aromatase enzyme activity, with Ki values of 14.4, 5.0 and 7.3 microM, respectively. The flavonoids, coumestrol, luteolin and kaempferol also decreased aromatase enzyme activity, with Ki values of 1.3, 4.8 and 27.2 microM, respectively. Aminoglutethimide, a pharmaceutical aromatase inhibitor, showed a Ki value of 0.5 microM. Kinetic studies showed the inhibition by all compounds to be competitive. Smaller decreases in aromatase activity were observed with the lignan, enterodiol (End) and its theoretical precursors, O-demethylsecoisolariciresinol (ODSI), demethoxysecoisolariciresinol (DMSI) and didemethylsecoisolariciresinol (DDSI). The flavonoids, O-demethylangolensin (O-Dma), fisetin and morin showed no inhibitory effects. The inhibition of human preadipocyte aromatase activity by lignans and flavonoids suggests a mechanism by which consumption of lignan- and flavonoid-rich plant foods may contribute to reduction of estrogen-dependent disease, such as breast cancer." @default.
- W1979078001 created "2016-06-24" @default.
- W1979078001 creator A5025838203 @default.
- W1979078001 creator A5047461080 @default.
- W1979078001 creator A5051948953 @default.
- W1979078001 creator A5068399609 @default.
- W1979078001 creator A5086365491 @default.
- W1979078001 date "1994-08-01" @default.
- W1979078001 modified "2023-10-05" @default.
- W1979078001 title "Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes" @default.
- W1979078001 cites W1483986092 @default.
- W1979078001 cites W1871934537 @default.
- W1979078001 cites W1946762839 @default.
- W1979078001 cites W1964500882 @default.
- W1979078001 cites W1969094690 @default.
- W1979078001 cites W1969121458 @default.
- W1979078001 cites W1969560406 @default.
- W1979078001 cites W1971241026 @default.
- W1979078001 cites W1973879040 @default.
- W1979078001 cites W1975747218 @default.
- W1979078001 cites W1985085751 @default.
- W1979078001 cites W2001536994 @default.
- W1979078001 cites W2008972850 @default.
- W1979078001 cites W2015931145 @default.
- W1979078001 cites W2018510674 @default.
- W1979078001 cites W2018868819 @default.
- W1979078001 cites W2022736585 @default.
- W1979078001 cites W2027078018 @default.
- W1979078001 cites W2027836418 @default.
- W1979078001 cites W2032221006 @default.
- W1979078001 cites W2037255793 @default.
- W1979078001 cites W2040564475 @default.
- W1979078001 cites W2049397968 @default.
- W1979078001 cites W2051156715 @default.
- W1979078001 cites W2059886775 @default.
- W1979078001 cites W2065564996 @default.
- W1979078001 cites W2075990964 @default.
- W1979078001 cites W2076637785 @default.
- W1979078001 cites W2079457273 @default.
- W1979078001 cites W2080392554 @default.
- W1979078001 cites W2081023575 @default.
- W1979078001 cites W2089268749 @default.
- W1979078001 cites W2090430385 @default.
- W1979078001 cites W2116535198 @default.
- W1979078001 cites W2118699735 @default.
- W1979078001 cites W2168041502 @default.
- W1979078001 cites W4293247451 @default.
- W1979078001 cites W4297928495 @default.
- W1979078001 doi "https://doi.org/10.1016/0960-0760(94)90030-2" @default.
- W1979078001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8049151" @default.
- W1979078001 hasPublicationYear "1994" @default.
- W1979078001 type Work @default.
- W1979078001 sameAs 1979078001 @default.
- W1979078001 citedByCount "298" @default.
- W1979078001 countsByYear W19790780012012 @default.
- W1979078001 countsByYear W19790780012013 @default.
- W1979078001 countsByYear W19790780012014 @default.
- W1979078001 countsByYear W19790780012015 @default.
- W1979078001 countsByYear W19790780012016 @default.
- W1979078001 countsByYear W19790780012017 @default.
- W1979078001 countsByYear W19790780012018 @default.
- W1979078001 countsByYear W19790780012019 @default.
- W1979078001 countsByYear W19790780012020 @default.
- W1979078001 countsByYear W19790780012021 @default.
- W1979078001 countsByYear W19790780012022 @default.
- W1979078001 countsByYear W19790780012023 @default.
- W1979078001 crossrefType "journal-article" @default.
- W1979078001 hasAuthorship W1979078001A5025838203 @default.
- W1979078001 hasAuthorship W1979078001A5047461080 @default.
- W1979078001 hasAuthorship W1979078001A5051948953 @default.
- W1979078001 hasAuthorship W1979078001A5068399609 @default.
- W1979078001 hasAuthorship W1979078001A5086365491 @default.
- W1979078001 hasConcept C121608353 @default.
- W1979078001 hasConcept C134018914 @default.
- W1979078001 hasConcept C142724271 @default.
- W1979078001 hasConcept C181199279 @default.
- W1979078001 hasConcept C185592680 @default.
- W1979078001 hasConcept C2776080593 @default.
- W1979078001 hasConcept C2776166826 @default.
- W1979078001 hasConcept C2777164284 @default.
- W1979078001 hasConcept C2777376040 @default.
- W1979078001 hasConcept C2777927066 @default.
- W1979078001 hasConcept C2778004101 @default.
- W1979078001 hasConcept C2778270713 @default.
- W1979078001 hasConcept C2779054382 @default.
- W1979078001 hasConcept C2779968248 @default.
- W1979078001 hasConcept C2781264555 @default.
- W1979078001 hasConcept C28212737 @default.
- W1979078001 hasConcept C530470458 @default.
- W1979078001 hasConcept C54355233 @default.
- W1979078001 hasConcept C55493867 @default.
- W1979078001 hasConcept C71240020 @default.
- W1979078001 hasConcept C71924100 @default.
- W1979078001 hasConcept C86803240 @default.
- W1979078001 hasConceptScore W1979078001C121608353 @default.
- W1979078001 hasConceptScore W1979078001C134018914 @default.
- W1979078001 hasConceptScore W1979078001C142724271 @default.
- W1979078001 hasConceptScore W1979078001C181199279 @default.