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- W1979078082 abstract "A recent fluorescence histochemical method for certain monoamines has been applied to a study of some aspects of the uptake and storage of exogenous catecholamines in adrenergic neurons. It was found, that the whole adrenergic neuron has the property to take up and concentrate noradrenaline and dopamine. This uptake was not inhibited if the amines were given to animals previously depleted of their endogenous catecholamines by reserpine. Since there is good evidence that the storage mechanism in the amine granules is inhibited by reserpine, it is likely that the amines accumulated in this way are present mainly in an extra-granular pool. The concentration of the amines was concluded to be much higher if the potent monoamine oxidase inhibitor nialamide was given before the administration of the amines. This suggests that monoamine oxidase is present in the neuron, and that the amines exist free or loosely bound in the cytoplasm, readily accessible to this enzyme. The mechanism for the accumulation of the amines seems to be localized to the cell membrane or the Schwann cell covering the axon." @default.
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- W1979078082 date "1964-06-01" @default.
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- W1979078082 title "Uptake and accumulation of catecholamines in peripheral adrenergic neurons of reserpinized animals, studied with a histochemical method" @default.
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- W1979078082 doi "https://doi.org/10.1016/0006-2952(64)90026-7" @default.
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