Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979080711> ?p ?o ?g. }
- W1979080711 endingPage "3155" @default.
- W1979080711 startingPage "3155" @default.
- W1979080711 abstract "Photochemical reactions of a variety of acylsilanes with peracetylated free glycosides in anhydrous benzene at ambient temperature yielded novel, highly acid-sensitive siloxyacetal glycosides in 75–90% yields with complete retention of configuration at the anomeric center. Subsequent deacetylation of triisopropylsiloxy- and tert-butyldimethylsiloxy derivatives with sodium methoxide in methanol afforded deprotected siloxyacetal glycosides in nearly quantitative yields. Acid hydrolysis of trimethylsilyl siloxyacetals proceeded with a half-life of 17.5 minutes at pH 6.2 which is vastly superior to the decomposition rate of conventional acetals under similar conditions. The structure of one of the novel siloxyacetals was confirmed by X-ray crystallography. In vitro biological studies showed that glucose-derived siloxyacetals may serve as potential pH-activated prodrugs for selective treatment of solid tumors." @default.
- W1979080711 created "2016-06-24" @default.
- W1979080711 creator A5051418877 @default.
- W1979080711 creator A5051707773 @default.
- W1979080711 creator A5074551571 @default.
- W1979080711 date "2004-01-01" @default.
- W1979080711 modified "2023-10-16" @default.
- W1979080711 title "Facile photochemical synthesis of mixed siloxyacetal glycosides as potential pH-sensitized prodrugs for selective treatment of solid tumors" @default.
- W1979080711 cites W1488317752 @default.
- W1979080711 cites W1666559762 @default.
- W1979080711 cites W1948560807 @default.
- W1979080711 cites W1966099909 @default.
- W1979080711 cites W1972685949 @default.
- W1979080711 cites W1975403190 @default.
- W1979080711 cites W1982542182 @default.
- W1979080711 cites W1985345549 @default.
- W1979080711 cites W1988366997 @default.
- W1979080711 cites W1996784782 @default.
- W1979080711 cites W1998868236 @default.
- W1979080711 cites W2002673390 @default.
- W1979080711 cites W2005592863 @default.
- W1979080711 cites W2008696046 @default.
- W1979080711 cites W2024351675 @default.
- W1979080711 cites W2034585139 @default.
- W1979080711 cites W2042051416 @default.
- W1979080711 cites W2042742974 @default.
- W1979080711 cites W2043028694 @default.
- W1979080711 cites W2047676254 @default.
- W1979080711 cites W2053898313 @default.
- W1979080711 cites W2071597072 @default.
- W1979080711 cites W2072261302 @default.
- W1979080711 cites W2075336395 @default.
- W1979080711 cites W2077739831 @default.
- W1979080711 cites W2084235230 @default.
- W1979080711 cites W2096841068 @default.
- W1979080711 cites W2099667786 @default.
- W1979080711 cites W2130758666 @default.
- W1979080711 cites W2169721093 @default.
- W1979080711 cites W2170966644 @default.
- W1979080711 cites W2317456816 @default.
- W1979080711 cites W2325822493 @default.
- W1979080711 cites W2326799823 @default.
- W1979080711 cites W2328305306 @default.
- W1979080711 cites W2330650366 @default.
- W1979080711 cites W2949589167 @default.
- W1979080711 cites W2951362778 @default.
- W1979080711 doi "https://doi.org/10.1039/b405786d" @default.
- W1979080711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15505722" @default.
- W1979080711 hasPublicationYear "2004" @default.
- W1979080711 type Work @default.
- W1979080711 sameAs 1979080711 @default.
- W1979080711 citedByCount "12" @default.
- W1979080711 countsByYear W19790807112013 @default.
- W1979080711 countsByYear W19790807112015 @default.
- W1979080711 countsByYear W19790807112020 @default.
- W1979080711 countsByYear W19790807112022 @default.
- W1979080711 countsByYear W19790807112023 @default.
- W1979080711 crossrefType "journal-article" @default.
- W1979080711 hasAuthorship W1979080711A5051418877 @default.
- W1979080711 hasAuthorship W1979080711A5051707773 @default.
- W1979080711 hasAuthorship W1979080711A5074551571 @default.
- W1979080711 hasConcept C108215921 @default.
- W1979080711 hasConcept C124681953 @default.
- W1979080711 hasConcept C178790620 @default.
- W1979080711 hasConcept C185592680 @default.
- W1979080711 hasConcept C187714232 @default.
- W1979080711 hasConcept C194671627 @default.
- W1979080711 hasConcept C21951064 @default.
- W1979080711 hasConcept C2777000832 @default.
- W1979080711 hasConcept C2777706827 @default.
- W1979080711 hasConcept C2779607525 @default.
- W1979080711 hasConcept C2781189857 @default.
- W1979080711 hasConcept C55493867 @default.
- W1979080711 hasConcept C7947691 @default.
- W1979080711 hasConcept C94412978 @default.
- W1979080711 hasConceptScore W1979080711C108215921 @default.
- W1979080711 hasConceptScore W1979080711C124681953 @default.
- W1979080711 hasConceptScore W1979080711C178790620 @default.
- W1979080711 hasConceptScore W1979080711C185592680 @default.
- W1979080711 hasConceptScore W1979080711C187714232 @default.
- W1979080711 hasConceptScore W1979080711C194671627 @default.
- W1979080711 hasConceptScore W1979080711C21951064 @default.
- W1979080711 hasConceptScore W1979080711C2777000832 @default.
- W1979080711 hasConceptScore W1979080711C2777706827 @default.
- W1979080711 hasConceptScore W1979080711C2779607525 @default.
- W1979080711 hasConceptScore W1979080711C2781189857 @default.
- W1979080711 hasConceptScore W1979080711C55493867 @default.
- W1979080711 hasConceptScore W1979080711C7947691 @default.
- W1979080711 hasConceptScore W1979080711C94412978 @default.
- W1979080711 hasIssue "21" @default.
- W1979080711 hasLocation W19790807111 @default.
- W1979080711 hasLocation W19790807112 @default.
- W1979080711 hasOpenAccess W1979080711 @default.
- W1979080711 hasPrimaryLocation W19790807111 @default.
- W1979080711 hasRelatedWork W1965735373 @default.
- W1979080711 hasRelatedWork W1971193052 @default.
- W1979080711 hasRelatedWork W1979080711 @default.
- W1979080711 hasRelatedWork W1985989090 @default.