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- W1979082849 abstract "In a solid-phase immunoassay, binding between an antigen and its specific antibody takes place at the boundary of a liquid and a solid phase. One of the reactants (receptor) is immobilized on a surface. The other reactant (ligand) is initially free in solution. We present a theory describing the kinetics of immunochemical reaction in such a system. A single essential restriction of the theory is the assumption that the reaction conditions are uniform along the binding surface. In general, the reaction rate as a function of time can be obtained numerically as a solution of a nonlinear integral equation. For some special cases, analytical solutions are available. Various immunoassay geometries are considered, in particular, the case when the reaction is carried out on a microspot." @default.
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- W1979082849 date "2005-06-01" @default.
- W1979082849 modified "2023-09-25" @default.
- W1979082849 title "Kinetics of protein binding in solid-phase immunoassays: Theory" @default.
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- W1979082849 doi "https://doi.org/10.1063/1.1927510" @default.
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